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ProteomicsEffect of PTEN knockout on dabrafenib-trametinib treatment in A375 melanoma cells - replicate 2
Approximately 50% of melanomas harbor an activating BRAFV600E mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the substrate for BRAF in the MAPK pathway. PTEN loss of function mutations occur in 40% of BRAFV600E melanomas, resulting in increased PI3K...
ORGANISM(S): Homo sapiens (Human) 
2024-04-23 | PXD033921 | Pride
A375 Kinase inhibitor Braf Melanoma Mek Kinome 
TranscriptomicsComparative Genomic Hybridizations of Mycoplasma gallisepticum Vaccine strains and strain Rlow
Genomic content of Vaccine strains were probed against the known sequence of the virulent strain Rlow of M. gallisepticum to identify divergent or absent genes in the attenuated strains. Genomic DNA was extracted from in vitro grown cultures of M. gallisepticum strains Rlow, F, ts-11, and 6/85 and t...
ORGANISM(S): Mycoplasma gallisepticum 
2010-05-16 | E-GEOD-19629 | biostudies-arrayexpress
UnknownPhase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
Not available
S-EPMC4500834 | biostudies-literature
GenomicsNCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
UnknownEfficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer.
Not available
S-EPMC5559902 | biostudies-literature
ProteomicsEffect of PTEN knockout on dabrafenib-trametinib treatment in A375 melanoma cells - replicate 1
Approximately 50% of melanomas harbor an activating BRAFV600E mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the substrate for BRAF in the MAPK pathway. PTEN loss of function mutations occur in 40% of BRAFV600E melanomas, resulting in increased PI3K...
ORGANISM(S): Homo sapiens (Human) 
2024-04-23 | PXD033866 | Pride
A375 Kinase inhibitor Braf Melanoma Mek Kinome 
UnknownDose-adjusted EPOCH-rituximab combined with fludarabine provides an effective bridge to reduced-intensity allogeneic hematopoietic stem-cell transplantation in patients with lymphoid malignancies.
Not available
S-EPMC3295571 | biostudies-literature
TranscriptomicsGene expression analysis of Influenza vaccine response in Young and Old - Year 1
We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old Differential gene expression by human PBMCs from Healthy Adults receiving Influenza Vaccination (Fluvirin, Novartis). Healthy adults (older >65, younger 21-30 years) were recruited ...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-59635 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Influenza vaccine response in Young and Old - Year 2
We profiled gene expression from a stratified cohort of subjects to define influenza vaccine response in Young and Old Differential gene expression by human PBMCs from Healthy Adults receiving Influenza Vaccination (Fluvirin, Novartis). Healthy adults (older >65, younger 21-30 years) were recruited ...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-59654 | biostudies-arrayexpress
MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
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