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GenomicsChIP-Seq of Dazl in mouse embryonic stem cells
We developed a method to identify chromatin-associated proteins by mass spectrometry. In addition to many known DNA and chromatin-binders, we identified several RNA-binding proteins in the chromatin composition of mouse embryonic stem cells (mESC). Interestingly, we found Dazl as a RBP that specific...
ORGANISM(S): Mus musculus 
2020-12-25 | E-MTAB-9302 | biostudies-arrayexpress
TranscriptomicsDazl is required for TET-mediated reprogramming to a naïve pluripotent state (II)
Embryonic stem cell (ESC) cultures display a heterogeneous gene expression profile, ranging from a pristine naïve pluripotent state to a primed epiblast state. While it is known that the addition of inhibitors of GSK3β and MEK (so-called 2i conditions) push ESC cultures towards a more homogeneous na...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-69356 | biostudies-arrayexpress
TranscriptomicsiCLIP of Dazl in mouse embryonic stem cells
In this experiment we would like to identify the binding sites of Dazl on the transcriptome of mESCs. To do that, we carried out an iCLIP experiment using mESCs grown in 2iL condition.
ORGANISM(S): Mus musculus 
2020-12-25 | E-MTAB-9332 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl UV RNA-IP)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39541 | biostudies-arrayexpress
TranscriptomicsDazl is required for TET-mediated reprogramming to a naïve pluripotent state (I)
Embryonic stem cell (ESC) cultures display a heterogeneous gene expression profile, ranging from a pristine naïve pluripotent state to a primed epiblast state. While it is known that the addition of inhibitors of GSK3? and MEK (so-called 2i conditions) push ESC cultures towards a more homogeneous na...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-69055 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl knockdown)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39535 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl native RNA-IP)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39544 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human embryonic stem cells over expressing NANOS3 and DAZL
Human embryonic stem cells (cell line HS401) were transfected with piggyBac over expression constructs for germ cell specific RNA binding proteins, Nanos homolog 3 (NANOS3) or Deleted in azoospermia-like (DAZL). Cells transfected with a construct without open reading frame (MOCK), were used as contr...
ORGANISM(S): Homo sapiens 
2016-10-19 | E-MTAB-3849 | biostudies-arrayexpress
GenomicsDAZL targets in undifferentiated spermatogonia
DAZL targets in undifferentiated spermatogonia
PRJNA605338 | ENA
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (in vitro, in vivo)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39546 | biostudies-arrayexpress
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