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GenomicsTargeting DCAF5 suppresses SMARCB1-mutant cancer via stabilizing SWI/SNF
Targeting DCAF5 suppresses SMARCB1-mutant cancer via stabilizing SWI/SNF
PRJNA888093 | ENA
GenomicsTargeting DCAF5 suppresses SMARCB1-mutant cancer via stabilizing SWI/SNF
Targeting DCAF5 suppresses SMARCB1-mutant cancer via stabilizing SWI/SNF
PRJNA888095 | ENA
GenomicsTargeting DCAF5 suppresses SMARCB1-mutant cancer via stabilizing SWI/SNF
Targeting DCAF5 suppresses SMARCB1-mutant cancer via stabilizing SWI/SNF
PRJNA888094 | ENA
GenomicsTargeting DCAF5 suppresses SMARCB1-mutant cancer via stabilizing SWI/SNF
While oncogenes can potentially be inhibited with small molecules, the loss of tumor suppressors is more common and presents a conundrum for precision therapy because the proteins are no longer present. SMARCB1-mutant cancers epitomize this challenge because these highly lethal cancers are driven by...
ORGANISM(S): Homo sapiens 
2024-03-22 | GSE215023 | GEO
GenomicsTargeting DCAF5 suppresses SMARCB1-mutant cancer via stabilizing SWI/SNF
While oncogenes can potentially be inhibited with small molecules, the loss of tumor suppressors is more common and presents a conundrum for precision therapy because the proteins are no longer present. SMARCB1-mutant cancers epitomize this challenge because these highly lethal cancers are driven by...
ORGANISM(S): Homo sapiens 
2024-03-22 | GSE215022 | GEO
TranscriptomicsTargeting DCAF5 suppresses SMARCB1-mutant cancer via stabilizing SWI/SNF
While oncogenes can potentially be inhibited with small molecules, the loss of tumor suppressors is more common and presents a conundrum for precision therapy because the proteins are no longer present. SMARCB1-mutant cancers epitomize this challenge because these highly lethal cancers are driven by...
ORGANISM(S): Homo sapiens 
2024-03-22 | GSE215024 | GEO
UnknownTargeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.
Not available
S-EPMC11184678 | biostudies-literature
ProteomicsA quality control factor for chromatin complexes is synthetic lethal in SMARCB1-mutant cancers
While oncogenes can potentially be inhibited with small molecules, the loss of tumor suppressors is more common and is problematic because the tumor suppressor proteins are no longer present to be targeted. Notable examples include SMARCB1-mutant cancers, which are highly lethal malignancies driven ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-21 | PXD046275 | Pride
Ubiquitin Dcaf5 Swi/snf Protein degradation Smarcb1 E3 ligase Chromatin 
ProteomicsA quality control factor for chromatin complexes is synthetic lethal in SMARCB1-mutant cancers
While oncogenes can potentially be inhibited with small molecules, the loss of tumor suppressors is more common and is problematic because the tumor suppressor proteins are no longer present to be targeted. Notable examples include SMARCB1-mutant cancers, which are highly lethal malignancies driven ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-21 | PXD046276 | Pride
Ubiquitin Dcaf5 Swi/snf Protein degradation Smarcb1 E3 ligase Chromatin 
ProteomicsA quality control factor for chromatin complexes is synthetic lethal in SMARCB1-mutant cancers
While oncogenes can potentially be inhibited with small molecules, the loss of tumor suppressors is more common and is problematic because the tumor suppressor proteins are no longer present to be targeted. Notable examples include SMARCB1-mutant cancers, which are highly lethal malignancies driven ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-21 | PXD046273 | Pride
Ubiquitin Cancer Dcaf5 Swi/snf Protein degradation Smarcb1 E3 ligase Chromatin 
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