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TranscriptomicsExpression profiling following SMARCB1 re-expression in MRT cell lines time course over 14 days
MRT cell lines KD, SWOH, LM, DEV and G401 were expression profiled following SMARCB1 re-expression using a lentivirus. Samples were taken at Day 0,1,3,7 and 14 and compared to empty vector control experiments.
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-6674 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to Smarcb1 re-expression in murine derived Smarcb1 deficient p53 null tumors
SMARCB1 (Snf5/Ini1/Baf47) is a potent tumor suppressor, the loss of which serves as the diagnostic feature in Malignant Rhabdoid Tumors (MRT) and Atypical Teratoid/Rhabdoid Tumors (AT/RT), two highly aggressive forms of pediatric neoplasms. Here, we restore Smarcb1 expression in cells derived from S...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-46017 | biostudies-arrayexpress
ProteomicsSMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity
Chromatin remodeling complexes, such as the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, play key roles in regulating gene expression by modulating nucleosome positioning. The core subunit SMARCB1 is essential for these functions, as it anchors the complex to the nucleosome acidic patch, enabli...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD062226 | Pride
Swi/snf Smarcb1 Chromatin Complex stability Cancer 
TranscriptomicsGene expression analysis of human haploid cells (HAP1) depleted of SMARCB1 and SMARCA4
The aim of this study is to analyze the change in genome wide expression levels in HAP1 cells upon loss of SMARCB1, SMARCA4 or both these genes together. The SMARCB1 and SMARCA4 genes were the hits from a genome wide screen involving genetrap mutagenesis to find new players that are involved in sen...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-75515 | biostudies-arrayexpress
GenomicsH3K27ac and SMARCB1 binding in control and SMARCB1-knockdown cells
H3K27ac and SMARCB1 binding in control and SMARCB1-knockdown cells
PRJNA506104 | ENA
ProteomicsGlobal proteomics and SWI/SNF interactomics in Epithelioid Sarcoma (EpS) upon rescue of SMARCB1
DOX-dependently SMARCB1-re-expressing, stable isogenic EpS cell line models were generated and submitted to global proteomic analysis as well as interactome analysis by co-immunoprecipitation of BRG1, one of the SWI/SNF core ATPases after 96h of DOX treatment.
ORGANISM(S): Homo sapiens (Human) 
2024-12-17 | PXD053945 | Pride
Swi/snf Smarca4/brg1 Smarcb1 Epithelioid sarcoma 
ProteomicsThe role of SMARCB1 in DNA Repair
This project studies the role of SMARCB1 in DNA Repair.
ORGANISM(S): Homo sapiens (Human) 
2026-03-26 | PXD069337 | Pride
Hek Smarcb1 Human 
GenomicsSMARCB1 knockdown in liver cancer cells
SMARCB1 knockdown in liver cancer cells
PRJNA419313 | ENA
GenomicsmSWI/SNF functional genomic characterization of SMARCB1 mutants in SMARCB1-null and heterozygous settings
mSWI/SNF functional genomic characterization of SMARCB1 mutants in SMARCB1-null and heterozygous settings
PRJNA514244 | ENA
GenomicsSMARCB1 knockdown in IMR90 and ARPE19
SMARCB1 knockdown in IMR90 and ARPE19
PRJNA494666 | ENA
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