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ProteomicsProteomic analysis of bone marrow cells from wild-type and Dcaf8 knockout mice
To explore the mechanisms by which DCAF8 deficiency induces functional defects in hematopoietic stem cells with an aging-like phenotype, and given DCAF8’s role as a substrate receptor in the E3 ubiquitin ligase complex, we conducted ubiquitin proteomic analysis on bone marrow cells from wild-type an...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-04 | PXD056221 | Pride
Dcaf8  bone marrow  aging 
ProteomicsUbiquitin proteomic analysis of bone marrow cells from wild-type and Dcaf8 knockout mice
To explore the mechanisms by which DCAF8 deficiency induces functional defects in hematopoietic stem cells with an aging-like phenotype, and given DCAF8’s role as a substrate receptor in the E3 ubiquitin ligase complex, we conducted ubiquitin proteomic analysis on bone marrow cells from wild-type an...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-04 | PXD056263 | Pride
Dcaf8  bone marrow  aging 
ProteomicsProteomic analysis of Lineage negative bone marrow cells from wild-type and Dcaf8 knockout mice
To explore the mechanisms by which DCAF8 deficiency induces functional defects in hematopoietic stem cells with an aging-like phenotype, and given DCAF8’s role as a substrate receptor in the E3 ubiquitin ligase complex, we conducted proteomic analysis on Lineage negative bone marrow cells from wild-...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-04 | PXD056107 | Pride
Aging Dcaf8 Bone marrow 
TranscriptomicsRNA-seq Analysis of Wild-Type and Dcaf8 Knockout LT-HSCs in Mice
Hematopoietic stem cell aging leads to dysfunction of hematopoietic and immune systems, which in return contribute to organismal aging and the development of aging-related diseases. Understanding the molecular mechanisms of HSC aging is critical for developing interventions to treat and prevent agin...
ORGANISM(S): Mus musculus 
2025-10-04 | GSE278044 | GEO
UnknownLoss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis.
Not available
S-EPMC12824705 | biostudies-literature
GenomicsMus musculus
RNA-seq Analysis of Wild-Type and Dcaf8 Knockout LT-HSCs in Mice
PRJNA1163985 | ENA
GenomicsSystematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor
Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor
PRJNA740837 | ENA
Methylation profilingSystematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor
Clonal hematopoiesis is a prevalent age-related condition associated with greatly increased risk of hematologic malignancies. Mutations in DNA methyltransferase 3A (DNMT3A) are the most common drivers of this state and contribute to multiple types of hematologic malignancy. DNMT3A variants occur acr...
ORGANISM(S): Homo sapiens Mus musculus 
2021-06-24 | GSE178798 | GEO
UnknownSystematic Profiling of <i>DNMT3A</i> Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
Not available
S-EPMC8758508 | biostudies-literature
TranscriptomicsCRL4DCAF8 Dependent Opposing Stability Control over Chromatin Remodeler LSH Governs the Epigenetic Dynamics in Ferroptosis
Despite the emerging evidence of ferroptosis implicated in diverse pathological scenarios, molecular adaptors linking its oxidative inducers and chromatin as carrier of stable epigenetic memory for its propagation remain elusive. Here, we report the identification of two WD40 proteins DCAF8 and WDR7...
ORGANISM(S): Homo sapiens 
2021-06-09 | GSE135361 | GEO
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