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ProteomicsBioID2-based proximity labeling identifies DDIT4-interacting proteins in human coronary artery smooth muscle cells
DDIT4 (DNA damage-inducible transcript 4) is a stress-responsive protein that has been implicated in vascular smooth muscle cell (VSMC) phenotypic switching and vascular remodeling. However, the comprehensive protein interaction network of DDIT4 in VSMCs remains poorly characterized. In this study, ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD083369 | Pride
Ddit4  bioid2  proximity labeling  protein-protein interactions  vascular smooth muscle cells  vsmc phenotypic switching  proteomics  biotinylation 
GenomicsGlucocorticoid inducton of DDIT4 transcription
Glucocorticoid inducton of DDIT4 transcription
PRJNA727062 | ENA
GenomicsDdit4 deficiency leads to a defect in AE9a induced leukemia development
Ddit4 deficiency leads to a defect in AE9a induced leukemia development
PRJNA1134614 | ENA
GenomicsREDD1/DDIT4 counteracts endoplasmic reticulum stress-induced apoptosis by controlling the expression of death receptor TRAILR2/DR5 in cancer cells.
REDD1/DDIT4 controls TRAILR2/DR5 expression.
PRJEB105045 | ENA
GenomicsHistone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblasts
Histone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblasts
PRJNA751578 | ENA
GenomicsKhellin Modulates DDIT4 to Regulate Autophagy in Triple-Negative Breast Cancer
Khellin Modulates DDIT4 to Regulate Autophagy in Triple-Negative Breast Cancer
PRJNA1430743 | ENA
GenomicsEnhancer reprogramming by SMYD2 drives DDIT4-dependent tumor progression and drug resistance in ccRCC
Enhancer reprogramming by SMYD2 drives DDIT4-dependent tumor progression and drug resistance in ccRCC
PRJNA1490504 | ENA
UnknownLong Non-coding Antisense RNA DDIT4-AS1 Regulates Meningitic Escherichia coli-Induced Neuroinflammation by Promoting DDIT4 mRNA Stability.
Not available
S-EPMC8882120 | biostudies-literature
UnknownDDIT4 Novel Mutations in Pancreatic Cancer.
Not available
S-EPMC8110378 | biostudies-literature
TranscriptomicsDdit4 deficiency leads to a defect in AE9a induced leukemia development
Our research indicated knock out of DDIT4 markedly suppresses leukemia initiation potential, leukemia maintenance and self-renewal of AE9a leukemia cells in vivo. To better understand the molecular mechanisms underlying the role of DDIT4 in self-renewal of LSC and leukemia initiation, we performed g...
ORGANISM(S): Mus musculus 
2025-12-04 | GSE272010 | GEO
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