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ProteomicsDDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation
DDX39B interacted with E3 ubiquitin ligase TRIM28 and underwent TRIM28-mediated K63-linked ubiquitination at Lys241, Lys384, and Lys398, leading to DDX39B protein stabilization and upregulation.
ORGANISM(S): Homo Sapiens 
PXD064812 |
ProteomicsMAP4K2 promotes Treg differentiation and suppresses antitumor immunity
MAP4K family kinases are key kinases for T-cell-mediated immune responses; however, in vivo roles of MAP4K2 in immune regulation remain unclear. Using T- cell-specific Map4k2 conditional knockout (T-Map4k2 cKO) mice, single-cell RNA sequencing (scRNA-seq), and mass spectrometry analysis, we found th...
ORGANISM(S): Homo sapiens (Human) 
2025-12-16 | PXD070831 | Pride
Map4k2 Ddx39b Foxp3 
ProteomicsMAP4K2 promotes Treg differentiation and suppresses antitumor immunity
MAP4K family kinases are key kinases for T-cell-mediated immune responses; however, in vivo roles of MAP4K2 in immune regulation remain unclear. Using T-cell-specific Map4k2 conditional knockout (T-Map4k2 cKO) mice, single-cell RNA sequencing (scRNA-seq), and mass spectrometry analysis, we found tha...
ORGANISM(S): Homo sapiens (Human) 
2025-12-16 | PXD070940 | Pride
Map4k2 Ddx39b Foxp3 Immunotherapy Treg 
GenomicsThe RNA-Binding Protein DDX39B Promotes Colorectal Adenocarcinoma Progression by Stabilizing DCLK1
The RNA-Binding Protein DDX39B Promotes Colorectal Adenocarcinoma Progression by Stabilizing DCLK1
PRJNA1261940 | ENA
GenomicsUnwinding the roles of DEAD-box RNA helicases DDX39A and DDX39B in alternative RNA splicing
Unwinding the roles of DEAD-box RNA helicases DDX39A and DDX39B in alternative RNA splicing
PRJNA1064916 | ENA
GenomicsSuppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA
Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA
PRJNA658317 | ENA
UnknownDDX39B promotes translation through regulation of pre-ribosomal RNA levels.
Not available
S-EPMC6284572 | biostudies-literature
TranscriptomicsUnwinding the roles of DEAD-box RNA helicases DDX39A and DDX39B in alternative RNA splicing
Dead-box RNA helicases are crucial in mRNA processing, specifically in RNA splicing. Our previous work has shown that DDX39B is responsible for regulating the splicing of IL7R exon 6 and several FOXP3 introns, which rely on DDX39B's helicase and ATPase activities, respectively [this is not accurate ...
ORGANISM(S): Homo sapiens 
2024-05-29 | GSE253261 | GEO
TranscriptomicsSuppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA
Multiple RNA processing events including transcription, mRNA splicing and export are delicately coordinated by the TREX complex. As one of the essential subunits, DDX39B couples the splicing and export machineries by recruiting ALYREF onto mRNA. In this study, we further explore the functions of DDX...
ORGANISM(S): Homo sapiens 
2020-08-21 | GSE156543 | GEO
UnknownDDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2.
Not available
S-EPMC9381590 | biostudies-literature
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