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TranscriptomicsGene regulation in ki-ras transfected murine fibroblasts
Ki-ras gene mutations are involved in the carcinogenesis of acute myeloid leukemia, melanoma and different carcinomas. In order to define potential mutation-specific therapeutic targets, expression profiling analyses were performed using stable transfected NIH3T3 cells carrying different ki-ras gene...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8372 | biostudies-arrayexpress
TranscriptomicsIdentification and validation of novel ERBB2 (HER2, NEU) targets including genes
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2; synonyms HER2, NEU) encodes a transmembrane glycoprotein with tyrosine kinase-specific activity that acts as a major switch in different signal-transduction processes. ERBB2 amplification and overexpression have been found in a number...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-16445 | biostudies-arrayexpress
TranscriptomicsGene regulation in Erbb2 transfected NIH3T3 cells using tet-off system
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2; synonyms HER2, NEU) encodes a transmembrane glycoprotein with tyrosine kinase-specific activity that acts as a major switch in different signal-transduction processes. ERBB2 amplification and overexpression have been found in a number...
ORGANISM(S): Mus musculus 
2009-09-01 | E-GEOD-8373 | biostudies-arrayexpress
TranscriptomicsGene regulation in Erbb2 transfected NIH3T3 cells after Azacytidine treatment
5-Azacytidine or 5-aza-2â??-deoxycytidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Cells in the presence of 5-azacytidine incorporate it into DNA during replication and RNA during transcription. The incorporation of 5-azacytidine into DNA or RNA inhibits methyltransfera...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-8374 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human blood from chronic lymphocytic leukemia patients before and after Fludarabine treatment
Transcription profiling of blood from human chronic lymphocytic leukemia patients before and after Fludarabine treatment
ORGANISM(S): Homo sapiens 
2010-09-01 | E-TABM-825 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of blood from human chronic lymphocytic leukemia patients before and after Fludarabine treatment
Molecular profile of Fludarabine refractory and sensitive CLLs
ORGANISM(S): Homo sapiens 
2010-09-01 | E-TABM-824 | biostudies-arrayexpress
TranscriptomicsmiR-10b*, a master inhibitor of the cell cycle, is downregulated in human breast tumors
Deciphering the molecular mechanisms involved in breast tumorigenesis has been the subject of extensive research in the last years; yet unpredictable response and development of resistance to adjuvant therapies remain major questions in the management of breast cancer patients. The power of miR expr...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-40525 | biostudies-arrayexpress
GenomicsGoT2D: Genetics of Type 2 Diabetes, a study of the the genetic architecture of type 2 diabetes using low pass whole genome sequencing and high density SNP genotyping in 2,657 individuals.
The Genetics of Type 2 Diabetes Consortium (GoT2D) is a collaboration between the University of Michigan, the Broad Institute and the Wellcome Trust Centre for Human Genetics. The overall aim is to extend upon recent efforts, such as genome-wide association studies (GWAS) and large scale meta-analys...
EGAS00001001459 | EGA
Genomicsena-DATASET-GoT2D/T2D-GENES-09-07-2016-02:03:47:226-1135 - samples
The GoT2D study includes ~2800 samples, half T2D cases and half T2D controls, of Northern European ancestry sequenced over 3 three technologies: deep whole exome sequencing, low-pass (4x) whole genome sequencing, and OMNI 2.5M genotyping. Samples were ascertained to be phenotypically "extreme" (e.g....
EGAD00001002247 | EGA
GenomicsT2D-GENES: Exome sequencing
The Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) is a large collaboration effort between the University of Michigan, Broad Institute, the Wellcome Trust Centre for Human Genetics, University of Chicago, NIDDK, Texas Biomedical Research Institu...
EGAS00001001460 | EGA
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