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UnknownSampling informational properties of codon usage through the tree of life.
The genetic code, a unifying principle in biology, ensures that all organisms, stemming from a Last Universal Common Ancestor (LUCA), share fundamental rules for translating DNA into proteins. However, codon usage varies across the tree of life, influenced not only by GC-content and proteome composi...
S-EPMC12654954 | biostudies-literature
UnknownMolecular and biophysical mechanisms behind the enhancement of lung surfactant function during controlled therapeutic hypothermia.
Therapeutic hypothermia (TH) enhances pulmonary surfactant performance in vivo by molecular mechanisms still unknown. Here, the interfacial structure and the composition of lung surfactant films have been analysed in vitro under TH as well as the molecular basis of its improved performance both unde...
S-EPMC7804441 | biostudies-literature
UnknownSanger sequencing in routine KRAS testing: a review of 1720 cases from a pathologist's perspective.

Background

Sanger sequencing (SS) of PCR products is still the most frequent method to test colorectal cancer for KRAS mutations in routine practice.

Methods

An audit of SS on 1720 routine cases was carried out, taking into account age, gender, specimen type (resection vs biopsies), t...
S-EPMC3461636 | biostudies-literature
UnknownmiR-4432 Targets FGFBP1 in Human Endothelial Cells.
MicroRNAs (miRs) are small non-coding RNAs that modulate the expression of several target genes. Fibroblast growth factor binding protein 1 (FGFBP1) has been associated with endothelial dysfunction at the level of the blood-brain barrier (BBB). However, the underlying mechanisms are mostly unknown a...
S-EPMC10045418 | biostudies-literature
UnknownAcute pharmacologic management of myocardial infarction in patients undergoing percutaneous coronary intervention: insights from the Italian nationwide EYESHOT-2 prospective registry.

Aims

International guidelines recommend specific antithrombotic strategies for acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). However, real-world practice often diverges. This study aimed to assess antithrombotic therapy use in AMI patients ad...
S-EPMC12686988 | biostudies-literature
UnknownIn-stent restenosis after percutaneous coronary intervention: emerging knowledge on biological pathways.
Percutaneous coronary intervention (PCI) has evolved significantly over the past four decades. Since its inception, in-stent restenosis (ISR)-the progressive reduction in vessel lumen diameter after PCI-has emerged as the main complication of the procedure. Although the incidence of ISR has reduced ...
S-EPMC10558044 | biostudies-literature
UnknownPatient adherence to and tolerability of self-administered interferon β-1a using an electronic autoinjection device: a multicentre, open-label, phase IV study.

Background

Achieving good adherence to self-injected treatments for multiple sclerosis can be difficult. Injection devices may help to overcome some of the injection-related barriers to adherence that can be experienced by patients. We sought to assess short-term adherence to, and tolerabili...
S-EPMC3368780 | biostudies-literature
UnknownCancer survivorship at heart: a multidisciplinary cardio-oncology roadmap for healthcare professionals.
In cancer, a patient is considered a survivor from the time of initial diagnosis until the end of life. With improvements in early diagnosis and treatment, the number of cancer survivors (CS) has grown considerably and includes: (1) Patients cured and free from cancer who may be at risk of late-onse...
S-EPMC10541962 | biostudies-literature
UnknownSalvage treatment with lenalidomide and dexamethasone in relapsed/refractory mantle cell lymphoma: clinical results and effects on microenvironment and neo-angiogenic biomarkers.

Background

Preclinical studies have highlighted the activity of lenalidomide in mantle cell lymphoma and its anti-proliferative synergy with dexamethasone.

Design and methods

In this prospective, multicenter, phase II study, patients with relapsed/refractory mantle cell lymphoma who w...
S-EPMC3291597 | biostudies-literature
TranscriptomicsGene expression profile of hemocytes from Manila clam (Venerupis philippinarum) after a Perkinsus olseni challenge using an immune-enriched oligo-microarray
Parasites of the genus Perkinsus spp. cause high mortalities and economic losses to the most noticeable bivalves produced in the worldwide aquaculture. In this study, we analyze how P. olseni influences the gene expression profiles of hemocytes from Manila clam (Venerupis philippinarum) using experi...
ORGANISM(S): Ruditapes philippinarum 
2015-07-31 | E-GEOD-59399 | biostudies-arrayexpress
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