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GenomicsA large fraction of extragenic RNA Pol II transcription sites overlap enhancers (2)
Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long non-coding RNAs (lncRNAs), some of which result from Pol_II transcription of bona-fide RNA genes. Whether all lncRNAs described insofar are product...
ORGANISM(S): Mus musculus 
2010-05-21 | E-GEOD-19991 | biostudies-arrayexpress
TranscriptomicsA large fraction of extragenic RNA Pol II transcription sites overlap enhancers
Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long non-coding RNAs (lncRNAs), some of which result from Pol_II transcription of bona-fide RNA genes. Whether all lncRNAs described insofar are product...
ORGANISM(S): Mus musculus 
2010-05-21 | E-GEOD-20370 | biostudies-arrayexpress
GenomicsIdentification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages
Enhancers determine tissue-specific gene expression programs. Enhancers are marked by high histone H3 lysine 4 mono-methylation (H3K4me1) and by the acetyl-transferase p300, which has allowed genome-wide enhancer identification. However, the regulatory principles by which subsets of enhancers become...
ORGANISM(S): Mus musculus 
2010-03-05 | E-GEOD-19553 | biostudies-arrayexpress
TranscriptomicsExpression quantitative trait loci (eQTL) analysis of mouse lung tumors
To detect genetic variations affecting gene expression in mouse lung tumor tissue, we carried out a genetic linkage study on the transcriptome of lung tumors induced by urethane in an (A/J x C57BL/6)F4 intercross population, whose individual lung tumor multiplicity (Nlung) is linked to the genotype ...
ORGANISM(S): Mus musculus 
2016-03-14 | E-GEOD-71232 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of monocyte derived human dentritic cells expsosed to fever-like temperature.
Normal human monocyte derived dentritic cells were subjected to fever-like thermal conditions (39M-0C) or to normal temperature (37M-0C) ) for 180 minutes, and global genome-wide gene expression profile was mesured using the human HG U133 plus array (Affymetrix).
ORGANISM(S): Homo sapiens 
2012-06-07 | E-MTAB-697 | biostudies-arrayexpress
GenomicsAorta- and liver-specific ERalpha binding patterns and gene regulation by estrogen (ChIP-seq)
Estrogen has vascular protective effects in premenopausal women and in women under 60 receiving hormone replacement therapy. However, estrogen also increases risks of breast and uterine cancers and of venous thromboses linked to upregulation of coagulation factors in the liver. In mouse models, the ...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-52351 | biostudies-arrayexpress
UnknownA pharmacogenetic interaction analysis of bevacizumab with paclitaxel in advanced breast cancer patients.
Not available
S-EPMC8938486 | biostudies-literature
UnknownErgonomics in the operating room and surgical training: a survey on the Italian scenario.
Not available
S-EPMC11337608 | biostudies-literature
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