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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
UnknownInsecticide-impregnated netting: A surface treatment for killing Lutzomyia longipalpis (Diptera: Psychodidae), the vector of Leishmania infantum.
Not available
S-EPMC8716342 | biostudies-literature
UnknownThe evolutionary history of manatees told by their mitogenomes.
Not available
S-EPMC7878490 | biostudies-literature
MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
ProteomicsProteomic signatures of schizophrenia-sourced iPSC-derived astrocytes
Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopmental origin. ??Molecul...
ORGANISM(S): Homo sapiens (Human) 
2023-04-27 | PXD031640 | Pride
Scz Glial cells Strocyte Disease Hipsc Proteome 
ProteomicsTNF-alpha stimulated secretome of schizophrenia-sourced iPSC-derived astrocytes
Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopmental origin. ??Molecul...
ORGANISM(S): Homo sapiens (Human) 
2023-04-27 | PXD031650 | Pride
Scz Glial cells Disease Hipsc Astrocyte Proteome Conditioned media 
MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
UnknownMetabolic reprogramming and gut microbiota ecology drive divergent Plasmodium vivax infection outcomes in Anopheles darlingi.
Not available
S-EPMC12758817 | biostudies-literature
UnknownAgreement between self-reported pre-pregnancy weight and measured first-trimester weight in Brazilian women.
Not available
S-EPMC7690094 | biostudies-literature
UnknownChemical composition, antinociceptive, anti-inflammatory and redox properties in vitro of the essential oil from Remirea maritima Aubl. (Cyperaceae).
Not available
S-EPMC4528852 | biostudies-literature
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