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ProteomicsProteomic signatures of schizophrenia-sourced iPSC-derived astrocytes
Schizophrenia is a complex and severe neuropsychiatric disorder, with a wide range of debilitating symptoms. Several aspects of its multifactorial complexity are still unknown, and some are accepted to be an early developmental deficiency with a more specifically neurodevelopmental origin. ??Molecul...
ORGANISM(S): Homo sapiens (Human) 
2023-04-27 | PXD031640 | Pride
Scz Glial cells Strocyte Disease Hipsc Proteome 
ProteomicsSingle-cell transcriptomics and cell-specific proteomics reveals new molecular regulators of sleep
Every day, we sleep for a third of the day. Sleep is important for cognition, brain waste clearance, metabolism, and immune responses. Homeostatic regulation of sleep is maintained by progressively rising sleep need during wakefulness, which then dissipates during sleep. The molecular mechanisms gov...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD018334 | Pride
Phosphoproteomics Differential proteomics Tandem mass tag Sleep deprivation Neuron Strocyte Single-cell rna sequencing Brainstem Hypothalamus Cortex 
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