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ProteomicsProteome analysis of brainstem organoids from human pluripotent stem cells
Brain organoids derived from human pluripotent stem cells recapitulate the course of human brain development. We applied proteomic analysis to human brainstem organoids which were developed by a novel method.
ORGANISM(S): Homo Sapiens (human) 
2020-05-01 | PXD016807 | JPOST Repository
ProteomicsApoptotic auditory brainstem of E13 chick embryo
We characterized the proteome of the auditory brainstem of a chick embryo on embryonic day 13, when apoptosis occurs in auditory nuclei. We identified caspase substrates by searching the peptidome for peptides C-terminal to caspase-typical cleavage sites.
ORGANISM(S): Gallus gallus (Chicken) 
2022-04-01 | PXD030697 | Pride
Auditory Chick Caspase Brainstem Apoptosis 
ProteomicsCaspase-3 cleaves extracellular vesicle proteins during auditory brainstem development
Sound localization requires extremely precise development of auditory brainstem circuits, the molecular mechanisms of which are largely unknown. We previously demonstrated a novel requirement for non-apoptotic activity of the protease caspase-3 in chick auditory brainstem development. Here, we used ...
ORGANISM(S): Gallus gallus (Chicken) 
2020-10-16 | PXD021728 | Pride
Neurodevelopment Chicken Brainstem Caspase-3 
Proteomicsphotoaffinity for Puerarin and mouse brainstem
To elucidate the molecular mechanism mediating the inactivated effect of DMV neurons on fat absorption, we performed an activity-based protein profiling strategy, using Puerarin as a “bait”. The Puerarin-tag probe was synthesized with a photoreactive tag to enrich and visualize target proteins via a...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-06 | PXD052140 | Pride
Puerarin brainstem 
ProteomicsQuantitative TMT proteomics of brainstem in spontaneously hypertensive rats
The brainstem, the core of the central nervous system, plays a vital role in controlling arterial blood pressure and its elevation of hypertension subtypes, especially essential hypertension. Integrative metabolic and proteomic profiling was performed on the brainstem samples of 11-week-old spontane...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-09-24 | PXD021210 | Pride
Quantitative proteome Tmt Brainstem Spontaneously hypertensive rats/shr rats 
TranscriptomicsGene expression data for three mouse auditory brainstem nuclei at two times of development
Genome-wide gene expression was obtained in three auditory brainstem nuclei (defined below), at two different ages in mice, postnatal day (P)3 and P14. The primary aim was to identify genes which are differentially expressed between the medial nucleus of the trapezoid body (MNTB) and the superior ol...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-46500 | biostudies-arrayexpress
TranscriptomicsDNA methylation alteration and gene expression sigature in brainstem, thalamic, and supratentorial gliomas
Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect due to their proximity to eloquent brain structures. Here, we performed a comprehesive genomic and epigenomic study, using gene expression and methylation microarrays, to research on th diffe...
ORGANISM(S): Homo sapiens 
2014-05-27 | E-GEOD-50774 | biostudies-arrayexpress
GenomicsMicroRNA expression data from brainstem gliomas
MicroRNA expression data from brainstem gliomas
PRJNA438947 | ENA
UnknownIntegrating brainstem and cortical functional architectures.
Not available
S-EPMC10705693 | biostudies-literature
UnknownIntegrating brainstem and cortical functional architectures.
Not available
S-EPMC10634864 | biostudies-literature
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