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ProteomicsCaspase-4 and Caspase-5 Coordinate the Sensing of Streptococcus pyogenes Extracellular vesicles
Caspase-4 and caspase-5 have been linked to the sensing of Gram-negative bacteria and their extracellular vesicles (EVs). Recent studies suggested that Gram-positive bacteria can be sensed through signaling cascades involving these two caspases. In the present study, we report that S. pyogenes secre...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD046570 | Pride
S. pyogenes Nlrp3 Caspases 
TranscriptomicsTH-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis
Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow. Advances in therapy and understanding of the metastatic process have been lim...
ORGANISM(S): Mus musculus 
2013-05-22 | E-GEOD-42254 | biostudies-arrayexpress
TranscriptomicsTH-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis
Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow. Advances in therapy and understanding of the metastatic process have been lim...
ORGANISM(S): Mus musculus 
2013-05-22 | E-GEOD-42548 | biostudies-arrayexpress
ProteomicsCaspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
The non-canonical inflammasome, consisting of caspase-4 in humans, initiates pyroptosis upon detecting cytosolic lipopolysaccharide (LPS) from Gram-negative bacteria. For its activation, caspase-4 binds the hydrophobic, membrane-embedded lipid A moiety of LPS, but how it accesses lipid A remains unk...
ORGANISM(S): Homo sapiens (Human) 
2026-03-10 | PXD070731 | Pride
Caspase-4 Immunology Lipopolysaccharide sensing Host-pathogen interaction gbp1 Membrane curvature Inflammasomes 
ProteomicsCaspase-3 cleaves extracellular vesicle proteins during auditory brainstem development
Sound localization requires extremely precise development of auditory brainstem circuits, the molecular mechanisms of which are largely unknown. We previously demonstrated a novel requirement for non-apoptotic activity of the protease caspase-3 in chick auditory brainstem development. Here, we used ...
ORGANISM(S): Gallus gallus (Chicken) 
2020-10-16 | PXD021728 | Pride
Neurodevelopment Chicken Brainstem Caspase-3 
ProteomicsIn vitro characterization of caspase-3 cleavage sites by LATE and HYATNE
Proteins' N-termini contain information about their biochemical properties and functions, and they can undergo co- or post-translational modifications, as well as be processed by proteases. To expand the coverage of the N-terminome, we have developed LATE (LysN Amino Terminal Enrichment), a method t...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD036593 | Pride
Late Hytane Lysn Peptidyl-lys metalloendopeptidase n-terminomics Caspase-3 
ModelsStucki2005 - caspase-3 metabolism
Jörg W. Stucki & Hans-Uwe Simon. Mathematical modeling of the regulation of caspase-3 activation and degradation. Journal of Theoretical Biology 234, 1 (2005). Caspases are thought to be important players in the execution process of apoptosis. Inhibitors of apoptosis (IAPs) are able to block caspas...
2024-09-02 | BIOMD0000001059 | BioModels
TranscriptomicsExpression data from the aortas of ApoE knockout, ApoE/Caspase-1 double knockout, and wild-type mice
Caspase-1 activation senses metabolic danger-associated molecular patterns and mediates the initiation of inflammation. Here, we reported that caspase-1 contributes to hyperlipidemia-induced modulation of vascular cell gene expression during early atherosclerosis in vivo. Our results demonstrate the...
ORGANISM(S): Mus musculus 
2015-08-21 | E-GEOD-72248 | biostudies-arrayexpress
TranscriptomicsHuman SV80 Cells: Control vs. Caspase-8 knock down
Excessive responses to pattern-recognition receptors are prevented by regulatory mechanisms that affect the amounts, conformation, and associative properties of their signaling proteins. We report that signaling by the ribonucleic acid sensor RIG-I is restricted, in addition, by caspase-mediated cle...
ORGANISM(S): Homo sapiens 
2011-02-07 | E-GEOD-23363 | biostudies-arrayexpress
ProteomicsCell-based characterization of caspase-3 cleavage sites by LATE and HYATNE
Proteins' N-termini contain information about their biochemical properties and functions, and they can undergo co- or post-translational modifications, as well as be processed by proteases. To expand the coverage of the N-terminome, we have developed LATE (LysN Amino Terminal Enrichment), a method t...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD036648 | Pride
Late Hytane Abt199 Lysn Peptidyl-lys metalloendopeptidase n-terminomics Caspase-3 
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