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ModelsStucki2005 - caspase-3 metabolism
Jörg W. Stucki & Hans-Uwe Simon. Mathematical modeling of the regulation of caspase-3 activation and degradation. Journal of Theoretical Biology 234, 1 (2005). Caspases are thought to be important players in the execution process of apoptosis. Inhibitors of apoptosis (IAPs) are able to block caspas...
2024-09-02 | BIOMD0000001059 | BioModels
ProteomicsCaspase-3 cleaves extracellular vesicle proteins during auditory brainstem development
Sound localization requires extremely precise development of auditory brainstem circuits, the molecular mechanisms of which are largely unknown. We previously demonstrated a novel requirement for non-apoptotic activity of the protease caspase-3 in chick auditory brainstem development. Here, we used ...
ORGANISM(S): Gallus gallus (Chicken) 
2020-10-16 | PXD021728 | Pride
Neurodevelopment Chicken Brainstem Caspase-3 
ProteomicsIn vitro characterization of caspase-3 cleavage sites by LATE and HYATNE
Proteins' N-termini contain information about their biochemical properties and functions, and they can undergo co- or post-translational modifications, as well as be processed by proteases. To expand the coverage of the N-terminome, we have developed LATE (LysN Amino Terminal Enrichment), a method t...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD036593 | Pride
Late Hytane Lysn Peptidyl-lys metalloendopeptidase n-terminomics Caspase-3 
OtherExecutioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart.
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00689 PASS00689]]. File: JAL_DanSanc_Hrt_iTRAQ_Fr6.mzml. Published as part of PLoS One. 2015 Jun 29;10(6):e0131411 . From the Abstract: {{i}} Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are be...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320017677 | GPMDB
ProteomicsCell-based characterization of caspase-3 cleavage sites by LATE and HYATNE
Proteins' N-termini contain information about their biochemical properties and functions, and they can undergo co- or post-translational modifications, as well as be processed by proteases. To expand the coverage of the N-terminome, we have developed LATE (LysN Amino Terminal Enrichment), a method t...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD036648 | Pride
Late Hytane Abt199 Lysn Peptidyl-lys metalloendopeptidase n-terminomics Caspase-3 
ProteomicsAnalysis of proteins interacting with cleaved caspase-3 under basal conditions in microglia cell line BV2
Assessing which proteins are interacting with cleaved caspase-3 under basal conditions in BV2 microglia cells
ORGANISM(S): Mus musculus (Mouse) 
2026-08-21 | PXD066997 | Pride
Immunoprecipitation Bruker Microglia Caspase-3 
ProteomicsCleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
Metabolic heterogeneity resulting from the intrinsic heterogeneity of human tumors has been shown to cause a myriad of adverse outcomes of tumor therapy, including resistance to chemotherapy, but the mechanisms inside remain largely unknown. Here, we found that the de novo pyrimidine synthesis pathw...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059365 |
ProteomicsBrucella suis S2 strain inhibits IRE1/Caspase-12/Caspase-3 pathway-mediated apoptosis of microglia HMC3 by affecting the ubiquitination of CALR
Neurobrucellosis is a serious complication of brucellosis, which poses a significant threat to human health and quality of life. The origin of this phenomenon is that the patients are more vulnerable to the development of chronic Brucella infection, which is also an important clinical problem. The r...
ORGANISM(S): Homo sapiens (Human) 
2025-02-20 | PXD056006 | Pride
Neurobrucellosis  brucella suis s2  endoplasmic reticulum stress  microglia  apoptosis 
TranscriptomicsIRF2 regulates macrophages apoptosis through a STAT1/3 and Caspase-1-dependent mechanism
Using microarray gene expression profiling of liver RNA samples rerived from IRF2+/+ and IRF2-/- mice treated with saline or LPS, we identified >40 genes that were significantly down-regulated in IRF2 -/- mice, including STAT3 which has been reported to regulate apoptosis. Keywords: compound treatme...
ORGANISM(S): Mus musculus 
2007-09-01 | E-GEOD-5907 | biostudies-arrayexpress
ProteomicsGel-Assisted Proteome Position Integral Shift (GAPPIS) Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Novel Caspase 3 Substrates
Here we present a high-throughput virtual top-down proteomics approach that restores the molecular weight (MW) information in shotgun proteomics, and demonstrate its utility in studying proteolytic events in programmed cell death. With Gel-Assisted Proteome Position Integral Shift (GAPPIS), we quant...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD049007 | Pride
Molecular weight，shotgun proteomics，mass spectrometry Caspase 3 Gel electrophoresis 
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