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ProteomicsCaspase-4 and Caspase-5 Coordinate the Sensing of Streptococcus pyogenes Extracellular vesicles
Caspase-4 and caspase-5 have been linked to the sensing of Gram-negative bacteria and their extracellular vesicles (EVs). Recent studies suggested that Gram-positive bacteria can be sensed through signaling cascades involving these two caspases. In the present study, we report that S. pyogenes secre...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD046570 | Pride
S. pyogenes Nlrp3 Caspases 
ProteomicsCaspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
The non-canonical inflammasome, consisting of caspase-4 in humans, initiates pyroptosis upon detecting cytosolic lipopolysaccharide (LPS) from Gram-negative bacteria. For its activation, caspase-4 binds the hydrophobic, membrane-embedded lipid A moiety of LPS, but how it accesses lipid A remains unk...
ORGANISM(S): Homo sapiens (Human) 
2026-03-10 | PXD070731 | Pride
Caspase-4 Immunology Lipopolysaccharide sensing Host-pathogen interaction gbp1 Membrane curvature Inflammasomes 
GenomicsCaspase-4 mediates SREBP1 activation in macrophages
Caspase-4 mediates SREBP1 activation in macrophages
PRJNA859704 | ENA
GenomicsFunctional analysis of Caspase-4 in non-small cell lung cancer cells
Functional analysis of Caspase-4 in non-small cell lung cancer cells
PRJNA985671 | ENA
ProteomicsTLR4 activation primes human macrophages for non-canonical caspase-4 inflammasome-induced extracellular vesicle secretion
Human macrophages secrete extracellular vesicles loaded with numerous immunoregulatory proteins. Here we employed high throughput quantitative proteomics to characterize the modulation of vesicle-mediated protein secretion during non-canonical caspase-4/5-dependent inflammasome activation. We show t...
ORGANISM(S): Homo sapiens (Human) 
2022-12-01 | PXD033002 | Pride
Caspase-4 Macrophages Proteomics Extracellular vesicles Interferon Non-canonical inflammasome 
TranscriptomicsCaspase-4 mediates SREBP1 activation in macrophages
We identified caspase-4/S1P/SREBP1 pathway that is activated in LPS-treated macrophages. To analyze the functions of caspase-4 and SREBP1 in gene expression in macrophages, we analyzed the effects of deletions of Casp4 and Srebf1 in bone marrow-derived macrophages by RNA-seq.
ORGANISM(S): Mus musculus 
2023-01-09 | GSE208374 | GEO
ProteomicsProteomic and bioinformatic characterization of proteins secreted conventionally and unconventionally from human primary macrophages upon LPS transfection
The non-canonical caspase-4/5 inflammasome has been only very recently characterized. It is expressed by macrophages, the principal effector cells of the innate immunity system, and is activated by gram-negative bacteria, ER stress, and UV radiation. Activation of this inflammasome results in pyropt...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080769 | MassIVE
TranscriptomicsFunctional analysis of Caspase-4 in non-small cell lung cancer cells
To clarify the role of Caspase-4 in non-small cell lung cancer cells, Caspase-4 overexpressing and knockout cells in NCI-H292 cells were established and each was analyzed by RNAseq.
ORGANISM(S): Homo sapiens 
2023-06-21 | GSE235296 | GEO
ProteomicsHuman Caspase-4 and -5 proteins have different expression profiles and biological functions
Inflammatory caspases are the central components of inflammasomes, among which the mouse Caspase-11 and human Caspase-4 and -5 are the core modules of non-canonical inflammasomes and function as the innate immune pattern recognition receptors (PRRs) for intracellular bacterial lipopolysaccharide (LP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-31 | MSV000089179 | MassIVE
GenomicsBile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through lncRNA57RIK
Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through lncRNA57RIK
PRJNA1161175 | ENA
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