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UnknownEffectiveness and Safety of Biosimilars in Pediatric Non-infectious Uveitis: Real-Life Data from the International AIDA Network Uveitis Registry.

Introduction

Since many biological drug patents have expired, biosimilar agents (BIOs) have been developed; however, there are still some reservations in their use, especially in childhood. The aim of the current study is to evaluate the efficacy and safety of tumor necrosis factor (TNF) inh...
S-EPMC10853125 | biostudies-literature
UnknownIncidence and Predictors of Ocular Complications in Pediatric-Onset Uveitis: Data from the AIDA Network Uveitis Registry.

Introduction

This study aims to describe complications of pediatric-onset uveitis and their predictors among baseline and treatment-related factors.

Methods

This registry-based observational study included patients with noninfectious uveitis with disease onset < 18 years.

Results

S-EPMC12534201 | biostudies-literature
UnknownThe Risk of Developing Ocular Involvement Among Behcet's Disease Patients Presenting with Mucocutaneous Involvement at Disease Onset: Data from the International AIDA Network Behcet's Disease Registry.

Introduction

Behçet's disease (BD) frequently arises with exclusively mucocutaneous involvement, but some patients will develop major organ involvement, including ocular inflammation. This study aims to assess the patients' demographic and clinical characteristics that may be associated with...
S-EPMC12882929 | biostudies-literature
UnknownGenetic Associations Between Modifiable Risk Factors and Alzheimer Disease.

Importance

An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk factors in the causal pathway to dementia.

Objective

S-EPMC10193187 | biostudies-literature
UnknownAssociation of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease.

Importance

The APOE ε2 and APOE ε4 alleles are the strongest protective and risk-increasing, respectively, genetic variants for late-onset Alzheimer disease (AD). However, the mechanisms linking APOE to AD-particularly the apoE protein's role in AD pathogenesis and how this is affected by AP...
S-EPMC9157381 | biostudies-literature
UnknownPolygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation.

Objectives

Polygenic hazard score (PHS) models can be used to predict the age-associated risk for complex diseases, including Alzheimer's disease (AD). In this study, we present an improved PHS model for AD that incorporates a large number of genetic variants and demonstrates enhanced predic...
S-EPMC12324663 | biostudies-literature
UnknownMachine learning in Alzheimer's disease genetics.
Traditional statistical approaches have advanced our understanding of the genetics of complex diseases, yet are limited to linear additive models. Here we applied machine learning (ML) to genome-wide data from 41,686 individuals in the largest European consortium on Alzheimer's disease (AD) to inves...
S-EPMC12280214 | biostudies-literature
Unknown<i>APOE</i> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease.
Among the more than 90 identified genetic risk loci for late-onset Alzheimer's disease (AD) and related dementias, the apolipoprotein E gene (APOE) ε2/ε3/ε4 polymorphism remains the longstanding benchmark for genetic disease risk with a consistently large effect across studies1-10....
S-EPMC12083631 | biostudies-literature
UnknownTransferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations.
A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal flu...
S-EPMC12283339 | biostudies-literature
UnknownCommon and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which iden...
S-EPMC8648564 | biostudies-literature
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