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MetabolomicsPFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

Aerobic glycolysis, termed the Warburg effect, is one of the aberrant metabolic pathways in highly proliferating cells. Glycolysis provides glycolytic metabolites to support the generation of biomass, such as nucleotides, amino acids, and lipids. To date, research on the direct interactions betwe...

2025-07-08 | MTBLS12688 | MetaboLights
MetabolomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma

Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. ...

2025-07-07 | MTBLS12461 | MetaboLights
ProteomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma
Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. How...
ORGANISM(S): Homo sapiens (Human) 
2025-07-08 | PXD063342 | Pride
Metabolic diversity De novo pyrimidine synthesis Neurofibromin 2 (nf2) Pleural mesothelioma (pm) Synthetic lethality 
ProteomicsDe novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defense
De novo pyrimidine biosynthesis is achieved by cytosolic enzymes, CAD and UMPS, and mitochondrial DHODH. However, how these enzymes are orchestrated remains enigmatical. Here, we show that cytosolic aspartate-producing GOT1 clusters with CAD and UMPS. This cytosolic cluster then connects with DHODH,...
ORGANISM(S): Homo Sapiens 
2023-03-22 | PXD041017 |
GenomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma
De Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma
PRJNA1255527 | ENA
GenomicsMetabolic Dependency on De Novo Pyrimidine Synthesis in Platinum Resistant Ovarian Cancer
Metabolic Dependency on De Novo Pyrimidine Synthesis in Platinum Resistant Ovarian Cancer
PRJNA1193543 | ENA
GenomicsDe novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity
De novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity
PRJNA1457363 | ENA
ProteomicsMetabolic Tracing Reveals IL-2 Driven Glutaminolysis and De Novo Pyrimidine Synthesis in Human Natural Killer Cells
Natural Killer (NK) cells are innate lymphocytes that are key to intrinsic cancer immunosurveillance and an important target for cancer immunotherapy. Understanding fundamental human NK cell metabolism provides opportunities for optimising NK cell therapies. Little is known about how glutamine, an i...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD076428 | Pride
Il2 Nk cells Glutaminolysis 
GenomicsPyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development [SCRB-seq]
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development [SCRB-seq]
PRJNA824310 | ENA
TranscriptomicsDe novo pyrimidine synthesis controls germinal center B cell and plasma cell fates and systemic autoimmunity
Whether and how pyrimidine metabolites promote systemic autoimmunity is unknown. Here, metabolomics and 15N-amide glutamine tracing show enhanced flux through de novo pyrimidine synthesis in SLE-prone B cells. Temporal inhibition of pyrimidine synthesis dampened SLE-prone but not foreign antigen-spe...
ORGANISM(S): Mus musculus 
2026-05-18 | GSE329002 | GEO
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