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MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
MetabolomicsAlcohol-Induced Bone Loss: Driven by Dysregulated Spatial Distribution of Gut Microbiota and PGD2-IL17 Pathway-Mediated Osteoclast Activation

Purpose: Alcohol-induced damage to bone microstructure leads to alcoholic osteopenia (AOP). While prior studies have demonstrated alcohol's negative impact on bone density, the mechanisms by which alcohol induces osteoporosis through immune pathways, gut microbiota dysbiosis, and metabolic altera...

2025-03-28 | MTBLS11887 | MetaboLights
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis
Not available
ORGANISM(S): Mus musculus 
ST002489 | MetabolomicsWorkbench
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - human plasma metabolomics
Not available
ORGANISM(S): Homo sapiens 
ST002490 | MetabolomicsWorkbench
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - mouse serum metabolomics
Not available
ORGANISM(S): Mus musculus 
ST002485 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human resting and IL2 activated natural killer cells
The aim of the study was to investigate the activation of human NK cells by IL2 through analyzing the global gene expression at different time points (0, 2, 8 and 24 hours) after culture with the cytokine IL2 at 100 IU/ml. NK cells with the CD56+/CD16+ and CD3- phenotype were negatively selected by ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-8059 | biostudies-arrayexpress
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - T-cell tracing supernatants
Not available
ORGANISM(S): Mus musculus 
ST002488 | MetabolomicsWorkbench
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - mouse blood T-cell metabolomics
Not available
ORGANISM(S): Mus musculus 
ST002486 | MetabolomicsWorkbench
MetabolomicsSimultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - mouse spleen and lymph node T-cell metabolomics
Not available
ORGANISM(S): Mus musculus 
ST002487 | MetabolomicsWorkbench
TranscriptomicsZBTB32 Is an Early Repressor of the CIITA MHC Class II Gene Expression during B Cell Differentiation to Plasma Cells
Primary murine B cells were stimulated with IL2, IL5, LPS to induce B cell differentiation for 24 hours. RNA was extracted from control and differentiated B cell to compare gene expression. Murine B cells (CD43-) were purfied from 5 weeks old mice splenocytes. And purified B cells were stimulated wi...
ORGANISM(S): Mus musculus 
2012-07-30 | E-GEOD-17999 | biostudies-arrayexpress
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