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GenomicsGenome-wide binding profiles of the B-Myb-MuvB complex in HeLa cells
To identify genomic regions bound by B-Myb and LIN9 (a subunit of the MuvB complex), we performed ChIP-Sequencing (ChIP-Seq) using chromatin from proliferating HeLa cells in which we can detect a robust association between B-Myb and subunits of the MuvB complex. This analysis allowed us identify lat...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-27030 | biostudies-arrayexpress
ProteomicsMDM2 degradation overcomes feedback regulation of p53 signaling in Merkel cellcarcinoma
This study explored the efficacy of MDM2 degraders, KTX-049 and KT-253, in treating Merkel cell carcinoma (MCC), an aggressive skin cancer. MCC tumors often exhibit clonal integration of Merkel cell polyomavirus, with virus-positive (MCCP) and virus-negative (MCCN) tumors showing distinct molecular ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-14 | PXD061890 | Pride
TranscriptomicsTranscriptional perturbations caused by SV40 large T antigen and its fragments
The small genome of polyomaviruses encodes a limited number of proteins that are highly dependent on interactions with host cell proteins for efficient viral replication. The SV40 large T antigen (LT) contains several discrete functional domains that contribute to the viral life cycle, including the...
ORGANISM(S): Homo sapiens 
2012-10-26 | E-GEOD-40567 | biostudies-arrayexpress
TranscriptomicsTranscriptional perturbations caused by tumor virus proteins
Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individual genomic variations. Genome sequencing efforts ha...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38467 | biostudies-arrayexpress
ProteomicsMudPIT analysis of STRN4 interacting proteins from HEK TER cells expressing either SV40 ST or GFP
HEK TER cells expressing either SV40 ST or GFP (30 x 15-cm diameter plates) were harvested with lysis buffer (20 mM imidazole HCl, 2 mM EDTA, 2 mM EGTA, pH 7.0 with 10 ug/mL each of aprotinin, leupeptin, pepstatin, 1 mM benzamidine, and 1 mM PMSF). The clarified cell extract was incubated overnight ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-12-05 | MSV000084662 | MassIVE
ProteomicsMudPIT analyses of the proteins co-purified with components of the LSD1 (KDM1A) transcriptional repressor complex and the non-canonical BAF complex, immuno-precipitated from MKL-1 and WaGa MCC cell lines
Protein Complexes Purification: Immunoprecipitations were performed with antibodies to LSD1 (2139; Cell signaling technology), INSM1 Mouse (SC-271408, Santa Cruz Biotechnology), RCOR2 (23969-1-AP; Proteintech Group), BRD9 (61537; Active Motif Rabbit), and normal Rabbit IgG (2729; Cell signaling tech...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-01-25 | MSV000083364 | MassIVE
UnknownIdentification of FAM111A as an SV40 host range restriction and adenovirus helper factor.
Not available
S-EPMC3475652 | biostudies-literature
UnknownInterpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
Not available
S-EPMC3408847 | biostudies-literature
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