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TranscriptomicsA comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation
Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransfera...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-11 | E-GEOD-9771 | biostudies-arrayexpress
TranscriptomicsVascular histone deacetylation by pharmacological HDAC inhibition [SAHA, RNA-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-54912 | biostudies-arrayexpress
TranscriptomicsVascular histone deacetylation by pharmacological HDAC inhibition [TSA, RNA-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-37376 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis plants treated with trichostatin A to block histone deacetylation or 5-aza-2-deoxycytosine to block cytosine methylation
Blocking histone deacetylation with trichostatin A (TSA) or blocking cytosine methylation using 5-aza-2'-deoxycytosine (aza-dC) can derepress silenced genes in multicellular eukaryotes, including animals and plants. We questioned whether DNA methylation and histone deacetylation overlap in the regul...
ORGANISM(S): Arabidopsis thaliana 
2007-05-10 | E-SMDB-4105 | biostudies-arrayexpress
ProteomicsDeacetylation inhibition reverses PABPN1-dependent muscle wasting
Reduced PABPN1 levels cause aging-associated muscle wasting. PABPN1 is a multi-functional regulator of mRNA processing. To elucidate the molecular mechanisms causing PABPN1-mediated muscle wasting, we compared the transcriptome to the proteome in mouse muscles expressing shRNA to PABPN1 (shPab). We ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD011534 | Pride
Mrna processing Muscle wasting Muscle proteome Sirt1 Muscle transcriptome Deacetylation 
Genomicstestosterone application induced H3K27 deacetylation
testosterone application induced H3K27 deacetylation
PRJNA1137417 | ENA
GenomicsHistone deacetylation-dependent and -independent transcriptional dysregulation in early-onset polyglutamine disease
Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcrip...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-44854 | biostudies-arrayexpress
GenomicsVascular histone deacetylation by pharmacological HDAC inhibition
Vascular histone deacetylation by pharmacological HDAC inhibition
PRJNA159705 | ENA
TranscriptomicsTranscription profiling of human hepatoma cells treated with 5-aza-dC, Trichostatin A, both, or control to elucidate the response to inhibition of DNA methylation and histone deacetylation
Expression profiling the response to inhibition of DNA methylation and histone deacetylation. Comparison of expression in HepG2 cells treated with 5-aza-dC, Trichostatin A, both, or none (control) to change methylation and acetylation status. Backgroubd: DNA methylation and histone deacetylation ar...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-5230 | biostudies-arrayexpress
GenomicsVascular histone deacetylation by pharmacological HDAC inhibition
This SuperSeries is composed of the SubSeries listed below. HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, how...
ORGANISM(S): Mus musculus 
2014-02-23 | E-GEOD-37378 | biostudies-arrayexpress
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