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TranscriptomicsCombinatorial binding of transcription factors in the pluripotency control regions of the genome
The pluripotency control regions (PluCRs) are defined as genomic regions that are bound by Oct4, Sox2, and Nanog in vivo. We utilized a high-throughput binding assay to record more than 270,000 different DNA/protein binding measurements along incrementally tiled windows of DNA within these PluCRs. T...
ORGANISM(S): Homo sapiens 
2011-03-03 | E-GEOD-27535 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of germinating wild type and pkl mutant Arabidopsis seeds treated with uniconazole-P
Relative expression data from germinating seeds of Columbia (wt), the pkl mutant (pkl), Columbia plus uniconazole-P (Uwt) and the pkl-mutant plus uniconazole-P (Upkl). Each experimental condition (wt, pkl, Uwt and Upkl) has four true replicates for a total of 16 chips.
ORGANISM(S): Arabidopsis thaliana 
2007-10-04 | E-GEOD-277 | biostudies-arrayexpress
TranscriptomicsmicroRNA suppresses prostate cancer stem cells and metastasis by inhibiting a cohort of pro-metastasis targets including CD44, Rho GTPases and EZH2
microRNA plays important roles in tumor initiation and progression. Here we showed that, one of the miR-200 family member, miR-141 is drastically under-expressed in several prostate cancer stem cell populations in both xenograft and primary patient samples. Enforced expression of miR-141 in CD44+ PC...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-71756 | biostudies-arrayexpress
UnknownSmart Medical Information Technology for Healthcare (SMITH).

Introduction

This article is part of the Focus Theme of Methods of Information in Medicine on the German Medical Informatics Initiative. "Smart Medical Information Technology for Healthcare (SMITH)" is one of four consortia funded by the German Medical Informatics Initiative (MI-I) to create...
S-EPMC6193398 | biostudies-literature
TranscriptomicsmiRNA expression of 3 prostate cell types from human normal donors
Prostate primary epithelial and stromal cells were isolated from normal donorhuman prostate tissue and patient prostate tumors (>Gleason 8) using in vitroselective media conditions and differential substrate adhesion properties.Tumor cells specific to the prostate epithelial cell component attached ...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-17323 | biostudies-arrayexpress
TranscriptomicsExpression data from human PBMC induced by mixed Congeners of PCBs at Human equivalence
Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of different diseases and disorders are not fully understood. The knowledge of global gene expression will help us to develop early disease or disorder bio...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-22668 | biostudies-arrayexpress
TranscriptomicsEWS/WT1 co-operates with the loss of p53 to exert its oncogenic effects and up-regulates canonical Wnt pathway signaling.
The t(11;22)(p13;q12) translocation is pathognomonic for the highly aggressive desmoplastic small round cell tumour (DSRCT). The translocation fuses exon 7 of the EWS gene to exon 8 of the WT1 gene (EWS/WT1). Two splice variants of EWS/WT1 exist, arising from the presence (+KTS) or absence (-KTS) of...
ORGANISM(S): Mus musculus 
2014-11-01 | E-GEOD-42649 | biostudies-arrayexpress
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