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MetabolomicsSphingosine-1-phosphate receptor 1 promotes ovarian cancer tumorsphere proliferation and metastasis
Despite extensive clinical endeavors to enhance high-grade serous ovarian cancer (HGSOC) detection and treatment, an alarming half of diagnosed women succumb annually to this disease. Significantly, nearly all HGSOC cases manifest ascites at diagnosis, a poor prognostic indicator. Malignant ascites ...
2026-03-04 | MTBLS13770 | MetaboLights
ModelsDeath Receptor Signaling
Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and cellular conditions. The mechanistic details of how a cell chooses among these cell fates are still unclear. The understanding of these processes is important since they are altered in many diseases, including c...
2084 | Cell Collective
MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
PXD056836 |
TranscriptomicsMechanism of cell death induced by saporin
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 These studies detail transcriptional changes induced in cancer cells by the complex of saporin (b-SO6) and the antibody fusion protein ch128.1Av...
ORGANISM(S): Homo sapiens 
2012-11-09 | E-GEOD-42138 | biostudies-arrayexpress
TranscriptomicsA Sphingosine 1-Phosphate 1 Receptor Agonist Modulates Brain Death-Induced Neurogenic Pulmonary Injury
Lung transplantation remains the only viable therapy for patients with end-stage lung disease; however, full utilization of this treatment strategy is severely compromised by the lack of donor lung availability. For example, the vast majority of donor lungs available for transplantation are obtained...
ORGANISM(S): Rattus norvegicus 
2010-07-30 | E-GEOD-22531 | biostudies-arrayexpress
ProteomicsA survival mechanism controlled by cadherins and Dlg1 polarity complex inhibits Fas cell death receptor signaling
A fine regulation of epithelia cell death is required to maintain tissue integrity and homeostasis. At a cellular level, this life and death decision is controlled by environmental stimuli including death receptors activation. Here, we show that establishment of cell polarity and AJ formation contro...
ORGANISM(S): Homo sapiens (Human) 
2018-09-20 | PXD009659 | Pride
Human Lc-msms Cell polarity Pdz Epithelia Death receptor Cell death 
TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
ProteomicsAndrogen receptor RIME using LNCaP cells
Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) was conducted to examine interactome of androgen receptor (AR) in LNCaP cells.
ORGANISM(S): Homo Sapiens (human) 
2021-09-10 | PXD024030 | JPOST Repository
TranscriptomicsGlobal transcriptomic profiling of nitric oxide-mediated neuronal death
Nitric oxide (NO) is implicated in the pathogenesis of various neuropathologies characterised by oxidative stress. NO has been reported to be involved in the exacerbation of oxidative stress by various mechanisms, including protein modification, genotoxic damage and elevated production of reactive o...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-22087 | biostudies-arrayexpress
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