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TranscriptomicsIGR_MEGACARYOCYTES_STUDY_OB
The molecular bases of cellular changes that occur during ontogeny of human megakaryopoiesis remained unknown. We performed global gene expression profiling of pure populations of megakaryocytes (MK) derived from ES cells (MKES), fetal liver (MKFL), cord blood (MKCB) and adult blood (MKAD). A close ...
ORGANISM(S): Homo sapiens 
2013-06-24 | E-MTAB-1452 | biostudies-arrayexpress
Unknownp19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.
Not available
S-EPMC4264042 | biostudies-literature
UnknownThrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.
Not available
S-EPMC3904625 | biostudies-literature
UnknownUncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint.
Not available
S-EPMC5479626 | biostudies-literature
UnknownDynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity.
Not available
S-EPMC6290100 | biostudies-literature
UnknownDisrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity.
Not available
S-EPMC6484462 | biostudies-literature
TranscriptomicsTranscription profiling of human tetraploid and polyploid (8N and 16N) megakaryocytes to identify genes which are up and down regulated during megakaryocyte differentiation/polyploidization
The aim of the experiment was to characterize by a pan-genomic approach genes which are continuously up and down regulated during polyploidization during megakaryocyte differentiation.
ORGANISM(S): Homo sapiens 
2007-04-16 | E-TABM-133 | biostudies-arrayexpress
UnknownP53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.
Not available
S-EPMC5077990 | biostudies-literature
TranscriptomicsTranscription profiling by array of the effect of S78454, a pan histone deacetylase inhibitor, on megakaryopoiesis derived from human CD34+ cells
S78454 (Abexinostat, PCI-24781) is a pan histone deacetylase inhibitor (HDACi) that demonstrates efficacy in malignancy treatment. Like other HDACi, this drug induces a profound thrombocytopenia, whose mechanism is partially understood. We have tested its effect at doses reached in patients plasma o...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-MTAB-1180 | biostudies-arrayexpress
UnknownLevel of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.
Not available
S-EPMC4347283 | biostudies-literature
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