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TranscriptomicsDOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs
Retinoic-acid receptor-related orphan receptor-γt-positive (RORγt+) innate lymphoid cells (ILCs) produce interleukin (IL)-22 and IL-17, which are critical for protective immunity against enteric pathogens. The molecular mechanism underlying the development and survival of RORγt+ ILCs is not thorough...
ORGANISM(S): Mus musculus 
2014-06-25 | E-GEOD-58765 | biostudies-arrayexpress
UnknownHaploidentical Related Donor Hematopoietic Stem Cell Transplantation for Dedicator-of-Cytokinesis 8 Deficiency Using Post-Transplantation Cyclophosphamide.
Not available
S-EPMC5757872 | biostudies-literature
UnknownDedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling.
Not available
S-EPMC4426039 | biostudies-literature
UnknownHyper IgE Syndrome Associated With Warts: A First Case of Dedicator of Cytokinesis 8 Deficiency in the Philippines.
Not available
S-EPMC7673426 | biostudies-literature
ProteomicsUSP36-mediated deubiquitination of DOCK4 contributes to the diabetic renal tubular epithelial cell injury via Wnt/β-catenin signaling pathway
Diabetic kidney disease (DKD) has become the leading cause of end-stage renal diseases, but the efficacy of current treatment remains unsatisfactory. The pathogenesis of DKD needs a more in-depth research. Ubiquitin specific proteases 36 (USP36), a member of deubiquitinating enzymes family, has arou...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023347 | Pride
Dedicator of cytokinesis 4 Deubiquitination Epithelial-to-mesenchymal transition Diabetic kidney disease Ubiquitin specific proteases 36 Wnt/β-catenin 
UnknownHematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency.
Not available
S-EPMC5354354 | biostudies-literature
ProteomicsThe proteome of human retrobulbar optic nerve
The optic nerve is a white matter tract that conveys visual information to the brain. A detailed investigation of the proteome of the normal human retrobulbar optic nerve may help facilitate studies of the biology and pathophysiology of the optic nerve. We conducted an in-depth proteomic analysis of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-13 | MSV000081934 | MassIVE
ProteomicsA Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia...
3xFLAG-IPs from HEK293T cell lysates expressing 3xFLAG-bait or 3xFLAG-control. Trypsin Digestion
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-09 | MSV000079100 | MassIVE
ProteomicsThe proteome of human retrobulbar optic nerve
The optic nerve is a white matter tract that conveys visual information to the brain. A detailed investigation of the proteome of the normal human retrobulbar optic nerve may help facilitate studies of the biology and pathophysiology of the optic nerve. We conducted an in-depth proteomic analysis of...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD001581 | Pride
Eye / human / optic nerve / proteome 
ProteomicsGamma secretase complex and DOCK2 affinity interactome.
γ-secretase is a transmembrane protease complex responsible for processing multiple type I transmembrane proteins, including the amyloid precursor protein and NOTCH. Despite various γ-secretase inhibitors and modulators developed in the past decades to target Notch-dependent cancers, their clinical ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-31 | PXD057036 | Pride
Nicastrin Dock2 Leukemia Gamma secretase Notch 
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