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MetabolomicsEndoplasmic reticulum-derived bodies enable a single-cell chemical defense in Brassicaceae plants
Brassicaceae plants have a dual-cell type of chemical defense against herbivory. Here we show a novel single-cell defense involving endoplasmic reticulum (ER)-derived organelles (ER bodies) and the vacuoles. We identify various glucosinolates as endogenous substrates of the ER-body β-glucosidases BG...
2020-02-04 | MTBLS1383 | MetaboLights
MetabolomicsSpecific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata
The native diploid tobacco Nicotiana attenuata produces abundant, potent anti-herbivore defense metabolites known as 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) whose glycosylation and malonylation biosynthetic steps are regulated by jasmonate signaling. To characterize the biosyntheti...
2021-10-06 | MTBLS1819 | MetaboLights
MetabolomicsDiurnal Dynamics Shape Plant Defense Responses: Temporal Variations in Disease Progression and Metabolic Reprogramming in Brassica oleracea
Plants synchronize their immune responses with the circadian cycle, yet the impact of diurnal timing on disease resistance remains poorly understood in crop species. In this study, we investigated how diurnal variation modulates defense responses in Brassica oleracea against Xanthomonas campestris p...
2025-08-22 | MTBLS7854 | MetaboLights
MetabolomicsDual transcriptomic & metabolomic analysis of elicited flax sheds light on the kinetics of immune defense activation against the biotrophic pathogen Oidium lini.
Flax (Linum usitatissimum) grown under controlled conditions displayed genotype-dependent resistance to powdery mildew (Oidium lini) following COS-OGA (comprising chitosan- and pectin-derived oligomers) elicitor application. The present study reveals a two-step immune response in plant...
2025-04-25 | MTBLS8263 | MetaboLights
MetabolomicsExploring Pinus nigra's induced defense arsenal against Diplodia sapinea through genes and metabolic pathway analysis

The European black pine (Pinus nigra J. F. Arnold) is a conifer of high economic and ecological importance, and a potential alternative to several forest tree species in Central Europe in response to global climate warming. Unfortunately, the fungus Diplodia sapinea (Fr.) Fuckel is causing severe...

2026-01-12 | MTBLS13216 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (DI-MS assays)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS117 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (GC-MS assay)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS118 | MetaboLights
MetabolomicsHemocyanin negatively regulates phenoloxidase activation via phenylalanine-tyrosine metabolism to enhance immune defense in AHPND-infected Penaeus vannamei
Hemocyanins function not only as oxygen carriers in the hemolymph of arthropods and molluscs but also as an important multifunctional immune molecule. In this study, we observed a significant increase in hemocyanin expression and a decrease in PO activity in Penaeus vannamei infected with acute hepa...
2026-05-22 | MTBLS14563 | MetaboLights
MetabolomicsExploring Pinus nigra's induced defense arsenal against Diplodia sapinea through genes and metabolic pathway analysis

Two years-old Pinus nigra saplings from two different provenances (Austria and Corsica) were infected with Diplodia sapinea. Needles from the terminal shoot (distant tissue where systemic induced response might take place) were sampled always in the morning. Samples were taken 3, 8 and 21 days af...

2026-01-12 | MTBLS13184 | MetaboLights
Metabolomics3,4-Dihydroxybenzaldehyde exerts anti-Alzheimer's effects by inhibiting Aβ protofibril assembly and activating antioxidant defense mechanisms

Broad-spectrum metabolomic analyses reveal that DBD markedly modulates the nematode’s metabolic profile. DBD enhances the activation of transcription factors DAF-16/FOXO and SKN-1/Nrf2, increasing resistance to oxidative and thermal stress. These findings suggest that DBD possesses multi-target t...

2025-12-24 | MTBLS13568 | MetaboLights
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