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MetabolomicsDiurnal Dynamics Shape Plant Defense Responses: Temporal Variations in Disease Progression and Metabolic Reprogramming in Brassica oleracea
Plants synchronize their immune responses with the circadian cycle, yet the impact of diurnal timing on disease resistance remains poorly understood in crop species. In this study, we investigated how diurnal variation modulates defense responses in Brassica oleracea against Xanthomonas campestris p...
2025-08-22 | MTBLS7854 | MetaboLights
MetabolomicsDual transcriptomic & metabolomic analysis of elicited flax sheds light on the kinetics of immune defense activation against the biotrophic pathogen Oidium lini.
Flax (Linum usitatissimum) grown under controlled conditions displayed genotype-dependent resistance to powdery mildew (Oidium lini) following COS-OGA (comprising chitosan- and pectin-derived oligomers) elicitor application. The present study reveals a two-step immune response in plant...
2025-04-25 | MTBLS8263 | MetaboLights
MetabolomicsSpecific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata
The native diploid tobacco Nicotiana attenuata produces abundant, potent anti-herbivore defense metabolites known as 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) whose glycosylation and malonylation biosynthetic steps are regulated by jasmonate signaling. To characterize the biosyntheti...
2021-10-06 | MTBLS1819 | MetaboLights
MetabolomicsAcute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways

Regular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, ...

2026-04-02 | MTBLS10972 | MetaboLights
MetabolomicsExploring Pinus nigra's induced defense arsenal against Diplodia sapinea through genes and metabolic pathway analysis

The European black pine (Pinus nigra J. F. Arnold) is a conifer of high economic and ecological importance, and a potential alternative to several forest tree species in Central Europe in response to global climate warming. Unfortunately, the fungus Diplodia sapinea (Fr.) Fuckel is causing severe...

2026-01-12 | MTBLS13216 | MetaboLights
MetabolomicsMaize Stem Response to Long-Term Attack by Sesamia nonagrioides
Plants defend themselves against herbivores by activating a plethora of genetic and biochemical mechanisms aimed at reducing plant damage and insect survival. The short-term plant response to insect attack is well understood, but less is known about the maintenance of this response over time. We per...
2018-05-16 | MTBLS575 | MetaboLights
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
MetabolomicsThe gut microbiota contributes to changes in the host immune response induced by Trichinella spiralis
The gut microbiota plays an important role in parasite-host interactions and the induction of immune defense responses. Trichinella spiralis is an important zoonotic parasite that can directly or indirectly interact with the host in the gut. Changes in the gut microbiota following infection with T. ...
2023-08-07 | MTBLS7603 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (DI-MS assays)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS117 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (GC-MS assay)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS118 | MetaboLights
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