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ProteomicsAtomic-Resolution Prediction of Degrader-mediated Ternary Complex Structures by Combining Molecular Simulations with Hydrogen Deuterium Exchange
Targeted protein degradation (TPD) has emerged as a powerful approach for removing (rather than inhibiting) proteins implicated in diseases. A key step in TPD is the formation of an induced proximity complex where a degrader molecule recruits an E3 ligase to the protein of interest (POI), facilitat...
ORGANISM(S): Homo sapiens (Human) 
2022-10-01 | PXD033763 | Pride
Lc-msms Degrader prediction Hela cells Ubiquitination mapping 
ProteomicsMechanism of degrader-targeted protein ubiquitinability
Small molecule degraders of disease-driving proteins offer a clinically proven modality with enhanced therapeutic efficacy and the potential to tackle previously undrugged targets. Thermodynamically stable and kinetically long-lived degrader-mediated ternary complexes can drive faster, more profound...
ORGANISM(S): Homo sapiens (Human) 
2024-11-08 | PXD053502 | Pride
Mz1 Vhl Ubiquitination 
GenomicsChIP-seq of trascription factors after SMARCA2/4 degrader treatment
ChIP-seq of trascription factors after SMARCA2/4 degrader treatment
PRJNA1180564 | ENA
ProteomicsDiscovery of a Highly Potent and Selective HDAC3 and HDAC8 PROTAC Dual Degrader
HDAC3 and HDAC8 are members of class I deacetylases involved in several biological mechanisms and represent a highly sought-after therapeutic target for drug development. It is historically challenging to develop selective deacetylase inhibitors due to their conserved catalytic domains. HDAC3 also h...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-20 | MSV000091511 | MassIVE
TranscriptomicsMicroarray analyses and miR-92a target prediction in primary mediastinal large B-cell lymphoma (PMBL) samples
Micro RNAs (miRNAs) are a class of small, non-coding RNAs that post-transcriptionally control the translation and stability of mRNAs. In our study, we found a higher level of miR-92a in PMBL versus DLBCL. A bioinformatics approach combining in silico prediction and transcriptomic analyses on patient...
ORGANISM(S): Homo sapiens 
2016-12-18 | E-MTAB-4165 | biostudies-arrayexpress
ProteomicsMAGL Targeted PROTAC Degrader Simultaneously Enhances P53 for Synergistic Treatment of Glioblastoma Stem Cell
This study focuses on the protein degradation effects of the MAGL inhibitor JZL184 and the newly synthesized MAGL-PROTAC on MAGL.
ORGANISM(S): Homo Sapiens 
2024-12-02 | PXD058506 |
UnknownDiscovery and prospects of new heterocyclic Isatin-hydrazide derivative with a novel role as estrogen receptor α degrader in breast cancer cells.
Not available
S-EPMC11252035 | biostudies-literature
TranscriptomicsWhole genome expression after modulation of miR-30a expression
A subset of breast cancer cells displays increased ability to self-renew and reproduce breast cancer heterogeneity (so called, breast tumour-initiating cells or BT-ICs). As microRNAs (miRNAs) control developmental programs in stem cells, BT-ICs may also rely on specific miRNA profiles for their sust...
ORGANISM(S): Homo sapiens 
2013-03-22 | E-GEOD-36565 | biostudies-arrayexpress
TranscriptomicsA novel YY1-miR-1 regulatory circuit in skeletal myogenesis revealed by genome-wide prediction of YY1-miRNA network
microRNAs (miRNAs) are non-coding RNAs that regulate gene expression post-transcriptionally, and mounting evidences support the prevalence and functional significance of their interplay with transcription factors (TFs). Here we describe the identification of a regulatory circuit between muscle miRNA...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-32238 | biostudies-arrayexpress
ProteomicsDCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug discovery. So far only a few ligases have been utilized for ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-18 | PXD047347 | Pride
Chemical proteomics 
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