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ProteomicsThe porcine granulocyte proteome: expression changes in a transgenic pig model for diabetes
As transgenic INSC94Y-pigs develop a stable diabetic phenotype we were able to study the influence of elevated blood glucose levels on primary immune cells in vivo. We investigated the neutrophil proteome and compared data of transgenic animals to a control group. A total of 2371 proteins describing...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-06-04 | PXD017274 | Pride
Differential proteomics Innate immune cell Neutrophil granulocyte Diabetes 
Proteomicsaltered bovine lymphocyte secretome after pokeweed mitogen stimulation
Vaccination with a new vaccine against bovine viral diarrhea (BVD) caused unwanted immune reactions through alloreactive antibody production in 5–10% of vaccinated cows. Transfer of these alloreactive antibodies via colostrum caused highly lethal (90%) bovine neonatal pancytopenia (BNP) in calves. D...
ORGANISM(S): Bos taurus (Bovine) 
2022-02-10 | PXD017892 | Pride
Immune system Polyclonal cell stimulation Ltq orbitrap xl. Bovine neonatal pancytopenia Vaccine Cow Deviant immune reactions 
ProteomicsChanges in bovine Lymphocyte proteome after stimulation with pokeweed mitogen
A new vaccine against bovine viral diarrhea (BVD) induced unwanted immune reactions with production of alloreactive antibodies in 5–10% of vaccinated cows. Transfer of these antibodies via colostrum caused bovine neonatal pancytopenia (BNP) in calves, with a lethality rate of 90%. The exact immunolo...
ORGANISM(S): Bos taurus (Bovine) 
2022-02-10 | PXD017350 | Pride
Pokeweed mitogen  polyclonal cell stimulation  immune reaction Cow 
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