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ProteomicsE. coli BW25113 and knock-out mutants (delta-pka, delta-arcA and delta-pka_arcA) LC MS/MS
1ml of WT, delta-pka, delta-arcA and delta-pka delta-arcA culture broth was harvested at u=0.4 h-1, centrifuged (14000 x g for 1 min at 4 degrees C), pellet washed once with PBS, flash frozen with liquid N2 and kept at -80 degrees C until further processing. Frozen pellets were melted on ice after w...
ORGANISM(S): Escherichia coli Acyrthosiphon pisum (Pea aphid) 
2014-03-19 | PXD000556 | Pride
Delta-pka Delta-pka_arca Delta-arca E. coli 
UnknownPKA and ERK1/2 are involved in dopamine D₁ receptor-induced heterologous desensitization of the δ opioid receptor.
Not available
S-EPMC3805374 | biostudies-literature
TranscriptomicsTranscription profiling by array of human HL60 cells treated with eicosapantaenoic acid (EPA) to investigate the effect on the signalling pathways involved in growth arrest/apoptosis
We investigated the effect of EPA on the signalling pathways involved in growth arrest/apoptosis in HL60 cells. EPA inhibited cell proliferation in HL60 cells in a dose dependent manner. Gene expression profiling of HL60 cells treated with EPA was performed by Affymetrix GeneChip. System and key mar...
ORGANISM(S): Homo sapiens 
2008-11-11 | E-MEXP-1389 | biostudies-arrayexpress
MetabolomicsF1Fo-ATP synthase subunit determines lethal pathogenic fungi infection
Fungal infections, especially candidiasis and aspergillosis, claim an unacceptably high fatality rate. The energy ATP that is necessary for fungal cell growth and function is synthesized mainly through oxidative phosphorylation, with the key enzyme being F1Fo-ATP synthase. But it remains unknown how...
2021-10-08 | MTBLS3332 | MetaboLights
TranscriptomicsGene expression in colorectal liver metastasis tissues from EPA-treated patients
Eicosapentaenoic acid in its free fatty acid form (EPA-FFA), 2g daily, is safe and well-tolerated in patients undergoing liver resection surgery for colorectal liver metastasis.Oral EPA incorporates into colorectal liver metastasis tissue. EPA-FFA treatment is associated with reduced vascularity of ...
ORGANISM(S): Homo sapiens 
2016-03-16 | E-GEOD-79266 | biostudies-arrayexpress
TranscriptomicsEffect of treatment OPM2 multiple myeloma cells with EPA, DHA or bortezomib
OPM2 cells were seeded in a 12-well plate at density of 10 × 103 cells/well and incubated with the indicated concentrations of compounds. OPM2 cells were treated with 50 µM of DHA/EPA (6 h) or 10 nM of bortezomib (4 h). Total RNA was extracted from cells using RNeasy Mini Kit (74104, Qiagen, Hilden,...
ORGANISM(S): Homo sapiens 
2022-06-26 | E-MTAB-11907 | biostudies-arrayexpress
UnknownProtein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
Not available
S-EPMC3129544 | biostudies-literature
ProteomicsF1Fo-ATP synthase subunit determines lethal infection in pathogenic fungi
Fungal infections, especially for candidiasis and aspergillosis, claim an unacceptably high fatality. However, the determining mechanism that promote fungal lethal infections are still elusive. The energy ATP necessary for fungal cell growth and function is synthesized mainly through oxidative phosp...
ORGANISM(S): Candida albicans (Yeast) 
2021-09-16 | PXD024729 | Pride
subunit lethal infection pathogenic fungi 
UnknownMitochondria complex I deficiency in Candida albicans arrests the cell cycle at S phase through suppressive TOR and PKA pathways.
Not available
S-EPMC11008738 | biostudies-literature
UnknownHypothalamic glucagon signals through the KATP channels to regulate glucose production.
Not available
S-EPMC3953686 | biostudies-literature
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