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ProteomicsDELTEX2 C-terminal domain recruits ADP-ribosylated DNA damage repair proteins for ubiquitination.
Crosstalk between ubiquitination and ADP-ribosylation regulates spatio-temporal recruitment of key players during DNA damage repair (DDR). The Deltex family of ubiquitin ligases (DTX1–4 and DTX3L), are characterized by a RING domain followed by a C-terminal domain (DTC) of unknown function; four Del...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD017807 | Pride
Par-binding domain Deltex c-terminal domain Parylation-dependent ubiquitination Dtx Dna damage 
UnknownDELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Not available
S-EPMC7442474 | biostudies-literature
UnknownMapping the Deltex-binding surface on the notch ankyrin domain using analytical ultracentrifugation.
Not available
S-EPMC3381501 | biostudies-literature
UnknownOligomerisation mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor.
Not available
S-EPMC10705365 | biostudies-literature
UnknownOligomerization mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor.
Not available
S-EPMC10955461 | biostudies-literature
UnknownDTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids.
Not available
S-EPMC11460948 | biostudies-literature
UnknownRegulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness.
Not available
S-EPMC2874642 | biostudies-literature
UnknownE3 ligase Deltex2 accelerates myoblast proliferation and inhibits myoblast differentiation by targeting Pax7 and MyoD, respectively.
Not available
S-EPMC10157619 | biostudies-literature
TranscriptomicsTranscription profiling of murine leukemic T cells from Ikaros-deficient mice and wild type mice to identify critical gene expression events during T-cell leukemogenesis.
The experiment was to compare leukemic T cells from thymic lymphomas from homozygote mice for the IkL/L hypomorphic mutation and non-transformed thymocytes, either of WT or IkL/L genotype. The aim was to identify a gene expression signature specific to the IkL/L tumors.
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2501 | biostudies-arrayexpress
TranscriptomicsGSI, Human T-ALL
The NOTCH signaling cascade, which is deregulated in T-cell acute lymphoblastic leukemia (T-ALL) and many other human cancers, offers an attractive target for molecular therapy. One approach employs gamma-secretase inhibitors (GSIs) to suppress production of the intracellular form of NOTCH (NICD), ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-8416 | biostudies-arrayexpress
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