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ProteomicsNUDT5 restrains PPAT to promote pyrimidine synthesis and effective nucleobase therapy - sgNUDT5 proteomics
Nucleotides are essential building blocks for nucleic acid synthesis, signaling, and metabolism. Rapidly proliferating cells require large amounts of nucleotides, making nucleotide metabolism a widely exploited target for cancer therapy. However, resistance frequently emerges, highlighting the need ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-29 | PXD060320 | Pride
Crispr screen Demethoxy-coenyzme q Nudt5 Pyrimidine Purine 
ProteomicsNUDT5 restrains PPAT to promote pyrimidine synthesis and effective nucleobase therapy - NUDT5 co-immunoprecipitation
Nucleotides are essential building blocks for nucleic acid synthesis, signaling, and metabolism. Rapidly proliferating cells require large amounts of nucleotides, making nucleotide metabolism a widely exploited target for cancer therapy. However, resistance frequently emerges, highlighting the need ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-29 | PXD060353 | Pride
Crispr screen Demethoxy-coenyzme q Nudt5 Pyrimidine Purine 
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