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ProteomicsNUDT5 restrains PPAT to promote pyrimidine synthesis and effective nucleobase therapy - NUDT5 co-immunoprecipitation
Nucleotides are essential building blocks for nucleic acid synthesis, signaling, and metabolism. Rapidly proliferating cells require large amounts of nucleotides, making nucleotide metabolism a widely exploited target for cancer therapy. However, resistance frequently emerges, highlighting the need ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-29 | PXD060353 | Pride
Crispr screen Demethoxy-coenyzme q Nudt5 Pyrimidine Purine 
ProteomicsNUDT5 restrains PPAT to promote pyrimidine synthesis and effective nucleobase therapy - sgNUDT5 proteomics
Nucleotides are essential building blocks for nucleic acid synthesis, signaling, and metabolism. Rapidly proliferating cells require large amounts of nucleotides, making nucleotide metabolism a widely exploited target for cancer therapy. However, resistance frequently emerges, highlighting the need ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-29 | PXD060320 | Pride
Crispr screen Demethoxy-coenyzme q Nudt5 Pyrimidine Purine 
GenomicsDeformability screening identifies NUDT5 as a mediator of cellular mechanobiology
Deformability screening identifies NUDT5 as a mediator of cellular mechanobiology
PRJNA1479855 | ENA
ProteomicsLarge-scale interaction proteomic profiling of NUDT5 and PPAT interactors
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. Here, we investigate the chemical and genetic dependencies caused by mutations in the folate enzyme MTHFD1 and discover a key role for Nudix hydr...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD067706 | Pride
Interaction proteomics 
ProteomicsTotal proteome analysis of NUDT5 PROTACs
6-Thioguanine (6-TG), an FDA-approved antimetabolite drug, is widely used in the treatment of leukemia. Its cellular effects require metabolic activation and are regulated through interactions with various proteins such as NUDT15, which catalyzes the hydrolysis of the active 6-TG metabolites 6-thio-...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD068003 | Pride
Protac 
TranscriptomicsDeformability screening identifies NUDT5 as a mediator of cellular mechanobiology
How cells deform, sense, and respond to mechanical cues drives physiological and disease processes ranging from development to cancer metastasis; however, unbiased approaches to identify mechanical mediators are lacking. We screened 1280 compounds to identify modulators of cancer cell deformability ...
ORGANISM(S): Homo sapiens 
2026-06-24 | GSE335942 | GEO
TranscriptomicsGenome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells
NUDT5 was reported to generate ATP to support local chromatin remodeling and transcription of hormone-responsive genes. Our research has found that NUDT5 is also required for DNA damage repair by homologous recombination. To investigate how NUDT5 regulates HR, we depleted NUDT5 in U2OS cells by siRN...
ORGANISM(S): Homo sapiens 
2023-02-14 | GSE196718 | GEO
GenomicsGenome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells
Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells
PRJNA806962 | ENA
TranscriptomicsGenome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [RNA-seq]
NUDT5 was reported to generate ATP to support local chromatin remodeling and transcription of hormone-responsive genes. Our research has found that NUDT5 is also required for DNA damage repair by homologous recombination. To investigate how NUDT5 regulates HR, we depleted NUDT5 in U2OS cells by siRN...
ORGANISM(S): Homo sapiens 
2023-02-14 | GSE196722 | GEO
GenomicsGenome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [ATAC-seq]
NUDT5 was reported to generate ATP to support local chromatin remodeling and transcription of hormone-responsive genes. Our research has found that NUDT5 is also required for DNA damage repair by homologous recombination. To investigate how NUDT5 regulates HR, we depleted NUDT5 in U2OS cells by siRN...
ORGANISM(S): Homo sapiens 
2023-02-14 | GSE196721 | GEO
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