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TranscriptomicsTranscriptional profiling of liver tissue from mice with wild-type, N750F mutant or exon 19 deleted RB1, after treatment with diethylnitrosamine.
The LXCXE peptide motif facilitates interaction between the RB tumor suppressor and a large number of cellular proteins that are expected to impinge on diverse biological processes. In vitro and in vivo analyses demonstrated that LXCXE-binding function is dispensable for RB promoter association and...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-31169 | biostudies-arrayexpress
TranscriptomicsGenomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment [expression data]
The retinoblastoma (RB) and p53 tumor suppressors are critical regulators of the cell cycle with profound impact on both normal cell biology and disease etiology. In the context of human cancers, compound inactivation of RB and p53 is a frequent occurrence; however, the cooperation of these tumor su...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-29846 | biostudies-arrayexpress
TranscriptomicsGene expression accompanying the promotion of hepatocellular carcinoma by intestinal microbiota and Tlr4 in mice.
The effect of Tlr4P712H mutation (rendering TLR4 non-functional), or gut-sterilization by antbiotics, on the induction of tumorgenesis by CCl4 and diethylnitrosamine (DEN) was characterized. Affymetrix Mouse 430 2.0 gene expression measurements were used to characterize the transcriptomic basis of t...
ORGANISM(S): Mus musculus 
2013-01-03 | E-GEOD-33446 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment
This SuperSeries is composed of the following subset Series: GSE29846: Genomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment [expression data] GSE29847: Genomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untr...
ORGANISM(S): Mus musculus 
2011-09-19 | E-GEOD-24347 | biostudies-arrayexpress
UnknownGenomic classifier identifies men with adverse pathology after radical prostatectomy who benefit from adjuvant radiation therapy.
Not available
S-EPMC4884273 | biostudies-literature
UnknownThe Role of the MYC/miR-150/MYB/ZDHHC11 Network in Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma.
Not available
S-EPMC8871936 | biostudies-literature
UnknownQuantified integrated hepatitis B virus is related to viral activity in patients with chronic hepatitis B.
Not available
S-EPMC9305117 | biostudies-literature
UnknownAirway wall thickness on HRCT scans decreases with age and increases with smoking.
Not available
S-EPMC5286807 | biostudies-literature
TranscriptomicsValidation of a genomic classifier that predicts metastasis following radical prostatectomy in at risk patient population
Purpose: Patients with locally advanced prostate cancer after radical prostatectomy are candidates for secondary therapy. However, this higher risk population is heterogeneous. Many cases do not metastasize even when conservatively managed. Given the limited specificity of pathological features to p...
ORGANISM(S): Homo sapiens 
2014-11-13 | E-GEOD-62116 | biostudies-arrayexpress
UnknownThe copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression.
Not available
S-EPMC3249196 | biostudies-literature
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