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MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
ProteomicsHuman melanoma-derived extracellular vesicles reprogram dendritic cells potentially enabling lymph node metastases
Evolution of melanoma from a primary tumor to widespread metastasis is crucially dependent on lymphatic spread. The mechanisms regulating the initial step in metastatic dissemination via regional lymph nodes remain largely unknown. We have previously described a dysfunctional immune profile that pre...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005539 | Pride
Metastasis4 Dendritic cells2 Lymphatics3 Extracellular vesicles1 Tumor immunology5 
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