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TranscriptomicsThe mechanosensory channel Piezo1 Triggers Angiopoietin-Tie Signaling in the Lymphatics
Angiopoietin-Tie1 signaling is required for lymphatic vascular integrity and both ANGPT2 and TIE1 genetic variants have been associated with lymphedema in patients1, 2. Concurrent with growth-factor signaling, mechanical forces sensed by lymphatic endothelial cells (LECs) are also needed to regulate...
ORGANISM(S): Mus musculus 
2024-03-05 | GSE211849 | GEO
ProteomicsHuman melanoma-derived extracellular vesicles reprogram dendritic cells potentially enabling lymph node metastases
Evolution of melanoma from a primary tumor to widespread metastasis is crucially dependent on lymphatic spread. The mechanisms regulating the initial step in metastatic dissemination via regional lymph nodes remain largely unknown. We have previously described a dysfunctional immune profile that pre...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005539 | Pride
Metastasis4 Dendritic cells2 Lymphatics3 Extracellular vesicles1 Tumor immunology5 
GenomicsThe mechanosensory channel Piezo1 Triggers Angiopoietin-Tie Signaling in the Lymphatics
The mechanosensory channel Piezo1 Triggers Angiopoietin-Tie Signaling in the Lymphatics
PRJNA872364 | ENA
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