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TranscriptomicsTenascin-C modifies expression levels and territories of key patterning genes during spinal cord astrocyte specification [mus musculus]
We demonstrate for the first time that the extracellular matrix glycoprotein Tenascin-C regulates the expression of key patterning genes during late embryonic spinal cord development, leading to a timely maturation of gliogenic neural precursor cells. We first show that Tenascin-C is expressed by gl...
ORGANISM(S): Mus musculus 
2011-10-19 | E-GEOD-33091 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of mouse ESC cardiomyocyte-specific differentiation
The differentiation to cardiomyocytes is a prerequisite and an important part of heart development. A good understanding of the complicated cardiomyocyte differentiation process benefits cardiogenesis study. Embryonic stem cells (ESCs), cell lines with infinite ability to proliferate and to be diffe...
ORGANISM(S): Mus musculus 
2014-09-25 | E-GEOD-58300 | biostudies-arrayexpress
TranscriptomicsNovel critical insights into the mechanism of cell-based therapy after myocardial infarction
Cell transplantation therapy is considered a novel and promising strategy in regenerative medicine. Recent studies point out that paracrine effects and inflammation induced by transplanted cells are key factors for the improvement of myocardial function. The present study aims at differentiating par...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-48218 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles of freshly isolated CD34+ cells and upon expansion on either tissue culture plastic (TCP) or mesenchymal stromal cells (MSCs)
Hematopoietic stem and progenitor cells (HPCs) can be maintained in vitro, but the vast majority of their progeny loses M-bM-^@M-^\stemnessM-bM-^@M-^] during culture. In this study, we have analyzed DNA methylation (DNAm) profiles of freshly isolated CD34+ cells and upon expansion on either tissue c...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-40799 | biostudies-arrayexpress
TranscriptomicsMatrix Elasticity Does Not Affect Replicative Senescence or DNA Methylation Patterns of Mesenchymal Stem Cells [DNAm profiling]
Matrix elasticity influences differentiation of mesenchymal stem cells (MSCs) but it is unclear if these effects are only transient - while the cells reside on the substrate - or if they reflect persistent lineage commitment. In this study, MSCs were continuously culture-expanded in parallel either ...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-55888 | biostudies-arrayexpress
TranscriptomicsIn vitro Expansion of Hematopoietic Stem Induces Gene Expression Changes
Hematopoietic stem and progenitor cells (HPCs) can be maintained in vitro, but the vast majority of their progeny loses M-bM-^@M-^\stemnessM-bM-^@M-^] during culture. We have analyzed DNA methylation (DNAm) profiles of freshly isolated CD34+ cells and upon expansion on either tissue culture plastic ...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-40669 | biostudies-arrayexpress
TranscriptomicsSurface Topography Enhances Differentiation of Mesenchymal Stem Cells Towards Osteogenic and Adipogenic Lineages
Surface topography impacts on cell growth and differentiation, but it is not trivial to generate homogeneous surface structures and to define the specific morphological parameters of relevance. In this study, we have compared gene expression profiles of mesenchymal stem cells (MSCs) on nanostructure...
ORGANISM(S): Homo sapiens 
2015-08-25 | E-GEOD-61113 | biostudies-arrayexpress
TranscriptomicsTranslation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation
Macrophage activation by bacterial lipopolysaccharides (LPS) is induced through Toll-like receptor 4 (TLR4). The synthesis and activity of TLR4 downstream signalling molecules modulates the expression of pro- and anti-inflammatory cytokines. To address the impact of post-transcriptional regulation o...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-48463 | biostudies-arrayexpress
TranscriptomicsReplicative senescence of mesenchymal stem cells causes DNA methylation changes which correlate with repressive histone marks
Cells in culture undergo replicative senescence. In this study, we analyzed functional, genetic and epigenetic sequels of long‐term culture in human mesenchymal stem cells (MSC). Already within early passages the fibroblastoid colony‐ forming unit (CFU‐f) frequency and the differentiation potential ...
ORGANISM(S): Homo sapiens 
2011-10-27 | E-GEOD-26519 | biostudies-arrayexpress
TranscriptomicsMatrix Elasticity Does Not Affect Replicative Senescence or DNA Methylation Patterns of Mesenchymal Stem Cells [gene expression profiling]
Matrix elasticity influences differentiation of mesenchymal stem cells (MSCs) but it is unclear if these effects are only transient - while the cells reside on the substrate - or if they reflect persistent lineage commitment. In this study, MSCs were continuously culture-expanded in parallel either ...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-55867 | biostudies-arrayexpress
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