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ProteomicsSox9 directs divergent epigenomic states in brain tumor subtypes
Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic alterations, however the molecular mechanisms responsible for these diverse epigenetic states remain unclear. Here we ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-07-13 | PXD033863 | Pride
Histone Transcription Epigenetics Ependymoma High grade glioma 
ProteomicsHistone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways
Bidirectional communication between tumors and neurons has emerged as a key facet of the tumor microenvironment that drives malignancy. Another hallmark feature of cancer is epigenomic dysregulation, where alterations in gene expression influences cell states and interactions with the tumor microenv...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-09 | PXD048170 | Pride
Epigenetic regulation Zfta-rela ependymoma Cancer neuroscience Developmental transcription factor 
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