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TranscriptomicsExpression data from human ependymoma
We compared molecular characteristics of primary and recurrent pediatric ependymoma to identify sub-group specific differences. Gene expression profiles were used to identify unique immunobiologic sub-types of posterior fossa pediatric ependymoma. Gene expression profiles were generated from surgica...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-50385 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse ependymomas: Comparative genomics matches mutations and cells to generate faithful ependymoma models
Genomic technologies have unmasked molecularly distinct subgroups among tumors of the same histological type; but understanding the biologic basis of these subgroups has proved difficult since their defining alterations are often numerous, and the cellular origins of most cancers remain unknown. We...
ORGANISM(S): Homo sapiens 
2010-07-19 | E-GEOD-21687 | biostudies-arrayexpress
TranscriptomicsInvestigation of the mechansim underlying the inflammatory phenotype in Group A ependymoma
Inflammatory response has been identified as a molecular signature of high-risk Group A ependymoma (EPN). To better understand the biology of this phenotype and aid therapeutic development, transcriptomic data from Group A and B EPN patient tumor samples, and additional malignant and normal brain da...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-66354 | biostudies-arrayexpress
TranscriptomicsExpression data from paediatric ependymoma short-term cell cultures
Promoter hypermethylation and transcriptional silencing is a common epigenetic mechanism of tumour suppressor inactivation in cancer, including malignant brain tumours. To identify targets of epigenetic silencing mediated by CpG island methylation in paediatric ependymoma, we used a pharmacological ...
ORGANISM(S): Homo sapiens 
2013-12-02 | E-GEOD-45437 | biostudies-arrayexpress
TranscriptomicsSpinal Ependymoma Gene Expression Data
Purpose: Myxopapillary ependymoma (MPE) is a distinct histological variant of ependymoma arising commonly in the spinal cord. Despite an overall favorable prognosis, distant metastases, subarachnoid dissemination, and late recurrences have been reported. Currently the only effective treatment for M...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-66787 | biostudies-arrayexpress
ProteomicsYAP/TAZ drives ependymoma-like tumour formation in mice
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuron...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD018131 | Pride
Brain Mus musculus Tmt10plex Nlsyap5sa Ependymoma 
GenomicsTherapeutic Targeting of Ependymoma as Informed by Oncogenic Enhancer Profiling
Genomic sequencing has driven precision-based oncology therapy; however, genetic drivers remain unknown or non-targetable for many malignancies, demanding alternative approaches to identify therapeutic leads. Ependymomas are chemotherapy-resistant brain tumours, which, despite genomic sequencing, la...
EGAS00001002696 | EGA
ProteomicsEZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma
Posterior fossa A (PFA) ependymomas comprise one out of nine molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young children, show a poor prognosis and are characterized by a lack of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark. Recently, we report...
ORGANISM(S): Homo sapiens (Human) 
2019-07-08 | PXD012318 | Pride
Prc2 Ezhip Cxorf67 Ependymoma 
TranscriptomicsHuman ependymoma samples [expression]
Whole-genome transcriptional profiling of human ependymoma tumors. Subgrouping based on mRNA expression profile. Fresh frozen tumor material was collected during tumor resection. Gene expression profiles illustrate distinct expression pattern at diagnosis.
ORGANISM(S): Homo sapiens 
2011-08-14 | E-GEOD-27283 | biostudies-arrayexpress
GenomicsBalanced Ependymoma
We propose to definitively characterise the somatic genetics of a number of pediatric malignant tumours including ependymoma, high grade glioma and central nervous system primitive neurectodermal tumours through generation of comprehensive catalogues of somatic mutations by high coverage genome sequ...
EGAS00001000174 | EGA
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