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GenomicsH3 K27M and EZHIP impede H3K27-methylation spreading by inhibing allosterically stimulated PRC2 [EZHIP]
H3 K27M and EZHIP impede H3K27-methylation spreading by inhibing allosterically stimulated PRC2 [EZHIP]
PRJNA637934 | ENA
GenomicsAberrant EZHIP Expression Drives Tumorigenesis in Osteosarcoma [RNA-Seq]
Aberrant EZHIP Expression Drives Tumorigenesis in Osteosarcoma [RNA-Seq]
PRJNA1006404 | ENA
GenomicsAberrant EZHIP Expression Drives Tumorigenesis in Osteosarcoma [CUT&RUN]
Aberrant EZHIP Expression Drives Tumorigenesis in Osteosarcoma [CUT&RUN]
PRJNA1006405 | ENA
ProteomicsEZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma
Posterior fossa A (PFA) ependymomas comprise one out of nine molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young children, show a poor prognosis and are characterized by a lack of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark. Recently, we report...
ORGANISM(S): Homo sapiens (Human) 
2019-07-08 | PXD012318 | Pride
Prc2 Ezhip Cxorf67 Ependymoma 
UnknownAberrant EZHIP expression drives tumorigenesis in osteosarcoma.
Not available
S-EPMC12284272 | biostudies-literature
UnknownEZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism.
Not available
S-EPMC12593861 | biostudies-literature
UnknownEZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.
Not available
S-EPMC6710278 | biostudies-literature
UnknownEZHIP in Pediatric Brain Tumors: From Epigenetic Mimicry to Therapeutic Vulnerabilities.
Not available
S-EPMC12842176 | biostudies-literature
GenomicsH3 K27M and EZHIP impede H3K27-methylation spreading by inhibing allosterically stimulated PRC2 [EZHIP]
In this study, we report that EZHIP and H3 K27M preferentially interact with an allosterically activated form of PRC2 in vivo. The formation of H3 K27M- and EZHIP-PRC2 complexes occurs at CpG islands containing H3K27me3 and impedes PRC2 and H3K27me3 spreading. Moreover, we find that H3 K27M inhibits...
ORGANISM(S): Mus musculus 
2020-10-12 | GSE151979 | GEO
UnknownH3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.
Not available
S-EPMC7680438 | biostudies-literature
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