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ProteomicsCxorf67-FLAG co-immunoprecipitation analysis from 293T cells
The regulation of gene expression is controlled in part by post-translational modifications to histone proteins. Methylation at histone H3, lysine 27 (H3K27), which is catalyzed by Polycomb repressive complex 2 (PRC2), is associated with silenced chromatin. Previous studies have identified dysregu...
ORGANISM(S): Homo sapiens (Human) 
2019-04-09 | PXD013390 | Pride
Epigenetics Cxorf67 H3k27me Prc2 Ezhip 
ProteomicsEZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma
Posterior fossa A (PFA) ependymomas comprise one out of nine molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young children, show a poor prognosis and are characterized by a lack of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark. Recently, we report...
ORGANISM(S): Homo sapiens (Human) 
2019-07-08 | PXD012318 | Pride
Prc2 Ezhip Cxorf67 Ependymoma 
GenomicsEZHIP / CXorf67 mimics oncohistones to inhibit PRC2 in PFA ependymoma
EZHIP / CXorf67 mimics oncohistones to inhibit PRC2 in PFA ependymoma
PRJNA525839 | ENA
TranscriptomicsEZHIP / CXorf67 mimics oncohistones to inhibit PRC2 in PFA ependymoma
Expression of CXorf67 is an oncogenic mechanism that drives H3K27 hypomethylation in PFA ependymomas by mimicking K27M mutated oncohistones. Background: Posterior fossa A (PFA) ependymomas comprise one out of nine molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young c...
ORGANISM(S): Homo sapiens 
2022-03-06 | GSE127941 | GEO
UnknownMolecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.
Not available
S-EPMC6105278 | biostudies-literature
UnknownElevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.
Not available
S-EPMC8455074 | biostudies-literature
UnknownEZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.
Not available
S-EPMC6620627 | biostudies-literature
GenomicsIdentification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma (aCGH)
Endometrial stromal sarcomas (ESSs) are a genetically heterogeneous group of rare uterine neoplasms that are frequently driven by recurrent gene rearrangements. In conventional low-grade ESSs, JAZF1-SUZ12, PHF1-JAZF1, EPC1-PHF1 and MEAF6-PHF1 chimeric fusions have been reported in > 50% of cases. Th...
ORGANISM(S): Homo sapiens 
2015-03-31 | GSE46284 | GEO
TranscriptomicsIdentification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma (expression)
Endometrial stromal sarcomas (ESSs) are a genetically heterogeneous group of rare uterine neoplasms that are frequently driven by recurrent gene rearrangements. In conventional low-grade ESSs, JAZF1-SUZ12, PHF1-JAZF1, EPC1-PHF1 and MEAF6-PHF1 chimeric fusions have been reported in >50% of cases. The...
ORGANISM(S): Homo sapiens 
2015-03-31 | GSE45783 | GEO
TranscriptomicsIdentification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma (aCGH)
Endometrial stromal sarcomas (ESSs) are a genetically heterogeneous group of rare uterine neoplasms that are frequently driven by recurrent gene rearrangements. In conventional low-grade ESSs, JAZF1-SUZ12, PHF1-JAZF1, EPC1-PHF1 and MEAF6-PHF1 chimeric fusions have been reported in > 50% of cases. Th...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-46284 | biostudies-arrayexpress
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