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YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuron...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD018131 | Pride
YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuronal ...
ORGANISM(S): Mus musculus 
2020-04-16 | GSE147961 | GEO
YAP/TAZ drives ependymoma-like tumour formation in mice
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