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ProteomicsN-Glycosylation-Defective IL6 Alternatively Activates the SRC-YAP-SOX2 Axis to Drive Metastasis and EGFR TKI Resistance
The IL6-GP130-STAT3 pathway facilitates lung cancer progression and resistance to tyrosine kinase inhibitors. Although glycosylation alters the stability of GP130, its effect on the ligand IL6 remains unclear. We herein found that N-glycosylated IL6, especially at Asn73, primarily stimulates JAK-STA...
ORGANISM(S): Homo sapiens (Human) 
2025-01-18 | PXD051771 | Pride
Il6  glycosylation  lung cancer  emt  metastasis  egfr-tki resistance  src  yap 
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
UnknownMaternal Fructose Intake During Pregnancy Induced the Hepatic Glucose Homeostasis Imbalance in the Offspring by Inhibiting Glucokinase.
Not available
S-EPMC12829521 | biostudies-literature
MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
UnknownHuman respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction.
Not available
S-EPMC11686133 | biostudies-literature
TranscriptomicsThe effects on transcriptome from absence of Spt4/Supt4h by RNA-seq
We have done RNAseq analyses in yeast and in rat and mouse striatal neurons. The experiments in yeast examine globally the physiological effects of spt4 deletion on the transcriptome. The experiments in neurons examine the global effects of supt4 knockdown to a cellular level (i.e., 50% knockdown)...
ORGANISM(S): Rattus norvegicus 
2012-02-15 | E-GEOD-33497 | biostudies-arrayexpress
UnknownA vitamin-C-derived DNA modification catalysed by an algal TET homologue.
Not available
S-EPMC6628258 | biostudies-literature
TranscriptomicsLoss of Olfactomedin 4 Leads to Neoplastic Progression in the Prostate
Purpose: To explore the mechanisms underlying increased tumorigenesis of Olfm4-deficient murine prostate. Experiment design: Comparison of gene expression between Olfm4-knockout and wild-type mice at 3 months of age in the prostate tissue. Experimental procedures: Total RNA was purified from whole p...
ORGANISM(S): Mus musculus 
2016-07-06 | E-GEOD-39989 | biostudies-arrayexpress
UnknownThe natural product phyllanthusmin C enhances IFN-γ production by human NK cells through upregulation of TLR-mediated NF-κB signaling.
Not available
S-EPMC4162489 | biostudies-literature
UnknownGenomic identification and functional analysis of essential genes in Caenorhabditis elegans.
Not available
S-EPMC6278001 | biostudies-literature
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