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MetabolomicsTranscriptomic and metabolomic analyses reveal the differential accumulation of phenylpropanoids and terpenoids in hemp autotetraploid and its diploid progenitor

Background

Cannabis sativa, a dioecious plant that has been cultivated worldwide for thousands of years, is known for its secondary metabolites, especially cannabinoids, which possess several medicinal effects. In this study, we investigated the autopolyploidization effects on the biosynthes...
2023-09-21 | MTBLS6032 | MetaboLights
ProteomicsLC-MS/MS to identify WT, 8NQ, N91/104/309/322Q and N91/104/309/322 B7H3 interaction
The specific N-glycans of glycoproteins play key roles in regulating protein localization, stability and activity. B7H3, an immune checkpoint molecule, is a highly N-glycosylated membrane protein. However, the key glycosylated asparagine (Asn) residues that mediate the function of the B7H3 protein a...
ORGANISM(S): Homo sapiens (Human) 
2025-03-27 | PXD059437 | Pride
Lc-ms/ms B7h3 
TranscriptomicsEnhanced Salicylic Acid Biosynthesis Is Involved in Heterosis for Bacterial Defense in Arabidopsis
We provide evidence that heterosis for bacterial defense exists in hybrids crossed between some Arabidopsis accessions. Comparison of transcriptomes between hybrids exhibiting heterosis for disease resistance and their parents after inoculation with Pst DC3000 revealed that several key genes involve...
ORGANISM(S): Arabidopsis thaliana 
2015-06-02 | E-GEOD-62256 | biostudies-arrayexpress
ProteomicsAffinity purification of TRMT6/61A protein complexes
In order to identify the molecular mechanism leading to the increase of TRMT6/61A complex in aged HSCs, we purified proteins interacting with TRMT6 and TRMT61A via affinity purification. HEK293T cells stably expressing SFB-tagged TRMT6 or SFB-TRMT61A were lysed in NETN buffer (20 mM Tris-HCl [pH 8.0...
ORGANISM(S): Homo Sapiens 
2023-11-30 | PXD047430 |
ProteomicsThe analysis of GSDME-NT binding proteins in the presence or absence of methionine
Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. Thus，the binding proteins of GSDME-NT are detected in the presence or absence of Methionine for futher exploration。
ORGANISM(S): Homo Sapiens 
2025-01-19 | PXD059954 |
ProteomicsThe analysis of spermidine-binding proteins
Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. This process is regulated by methionine metabolite spermidine，which can bind with proteins to regulate their biological function. Thus，the binding proteins of sp...
ORGANISM(S): Homo Sapiens 
2025-01-21 | PXD060003 |
ProteomicsArid3b suppresses CD8+ T cell infiltration and function in Microsatellite-stable colorectal cancer via Runx3
Microsatellite stable/proficient mismatch repair (MSS/pMMR) colorectal cancer (CRC) is characterized by a cold tumor microenvironment, marked by sparse CD8⁺ T cell infiltration and resistance to immune checkpoint inhibitors (ICIs). To uncover regulators that limit CD8⁺ T cell infiltration in MSS CRC...
ORGANISM(S): Mus Musculus 
2026-04-16 | PXD077233 |
ProteomicsTandem proteomic and N-glycoproteomic analysis of extracellular vesicles
Extracellular vesicles (EVs) derived from diverse biofluids have emerged as promising noninvasive diagnostic biomarkers or signatures for various diseases. EV-associated N-glycoproteins are crucial for the biological functions of EVs and hold significant potential for disease diagnosis and prognosis...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057512 |
Proteomicsproteomic and N-glycoproteomic analysis of extracellular vesicles for biofluids
Extracellular vesicles (EVs) derived from diverse biofluids have emerged as promising noninvasive diagnostic biomarkers or signatures for various diseases. EV-associated N-glycoproteins are crucial for the biological functions of EVs and hold significant potential for disease diagnosis and prognosis...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057515 |
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