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MetabolomicsPalmitic Acid-Triggerd B7H3 Palmitoylation Promotes Immune Escape

B7H3 (CD276), a key immune checkpoint molecule that is overexpressed in tumors, plays a central role in cancer progression, making it a highly promising and specific therapeutic target. Here, we discovered that the cellular metabolite palmitic acid contributes to the development of an immunosuppr...

2025-12-03 | MTBLS12300 | MetaboLights
MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
ProteomicsLC-MS/MS to identify WT, 8NQ, N91/104/309/322Q and N91/104/309/322 B7H3 interaction
The specific N-glycans of glycoproteins play key roles in regulating protein localization, stability and activity. B7H3, an immune checkpoint molecule, is a highly N-glycosylated membrane protein. However, the key glycosylated asparagine (Asn) residues that mediate the function of the B7H3 protein a...
ORGANISM(S): Homo sapiens (Human) 
2025-03-27 | PXD059437 | Pride
Lc-ms/ms B7h3 
ProteomicsIndentification of B7H3 WT/NQ N-Glycosites
Most patients with triple negative breast cancer (TNBC) fail to respond to anti-PD1/PDL1 immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a highly glycosylated protein. However, the mechanisms of B7H3 glycosylation regulation and whether the sugar moiety contribu...
ORGANISM(S): Homo sapiens (Human) 
2021-03-15 | PXD024672 | Pride
Glycosites Breast cancer B7h3 
GenomicsRNA seq analysis of GD2-B7H3 gated CAR-T cells versus conventional B7H3 CAR-T cells
RNA seq analysis of GD2-B7H3 gated CAR-T cells versus conventional B7H3 CAR-T cells
PRJNA679955 | ENA
TranscriptomicsRNA seq analysis of GD2-B7H3 gated CAR-T cells versus conventional B7H3 CAR-T cells
Purpose: Next-generation sequencing (NGS) has revolutionized the systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived transcriptome profiling (RNA-seq) between two generations of CAR-T cells aimed at integrating their fitness to overcome exhaustion and stre...
ORGANISM(S): Homo sapiens 
2020-11-30 | GSE161942 | GEO
UnknownClinical relevance of B7H3 expression in retinoblastoma.
Not available
S-EPMC7311428 | biostudies-literature
UnknownPalmitic acid-triggered B7H3 palmitoylation promotes immune escape.
Not available
S-EPMC12917163 | biostudies-literature
GenomicsTumor-derived biomarkers beyond antigen expression enhance efficacy of CD276/B7H3 antibody-drug conjugate in metastatic prostate cancer
Tumor-derived biomarkers beyond antigen expression enhance efficacy of CD276/B7H3 antibody-drug conjugate in metastatic prostate cancer
PRJNA992487 | ENA
UnknownSurvival Association and Cell Cycle Effects of B7H3 in Neuroblastoma.
Not available
S-EPMC7671786 | biostudies-literature
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