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TranscriptomicsExposure to Cobalt Causes Transcriptomic and Proteomic Changes in Two Rat Liver Derived Cell Lines
Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic, long term exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, as ...
ORGANISM(S): Rattus norvegicus 
2013-12-01 | E-GEOD-51207 | biostudies-arrayexpress
TranscriptomicsTemporal Changes in Rat Liver Gene Expression after Acute Cadmium and Chromium Exposure
U.S. Service Members and civilians are at risk of exposure to a variety of environmental health hazards throughout their normal duty activities and in industrial occupations. Metals are widely used in large quantities in a number of industrial processes and are a common environmental toxicant, which...
ORGANISM(S): Rattus norvegicus 
2015-05-21 | E-GEOD-65198 | biostudies-arrayexpress
ProteomicsParenchymal and Dyshorric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2
Whole brain tissue proteomics from rat models of cerebral small vessel disease and Alzheimer's disease, including the rTg-DI model of Cerebral Amyloid Angiopathy (CAA) Type-1, the rTg-D model of CAA Type-2 with both hemizygous and homozygous animals, and the TgSD-AD model of Alzheimer's Disease.
ORGANISM(S): Rattus norvegicus (Rat) 
2025-11-17 | PXD061304 | Pride
Cerebral amyloid angiopathy Preclinical model Alzheimer's disease Cerebral small vessel disease 
TranscriptomicsTranscription profiling of Caenorhabditis elegans treated with Dichlorvos and fenamiphos, to investigate it as a genomic model for toxicology
Effective toxicological testing of the vast number of new and existing chemicals currently in use will require efficient and cost effective methods. We evaluated the utility of a simple, low cost toxicity testing system employing the nematode Caenorhabditis elegans to identify toxicologically releva...
ORGANISM(S): Caenorhabditis elegans 
2009-06-24 | E-GEOD-12298 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblasts synchronized and treated with 1.5 Gy irraditation to identify primary transcriptional regulation of cell-cycle-regulated genes upon DNA damage
The changes in global gene expression in response to DNA damage may derive from either direct induction or repression by transcriptional regulation or indirectly by synchronization of cells to specific cell cycle phases, such as G1 or G2. We developed a model that successfully estimated the express...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7075 | biostudies-arrayexpress
TranscriptomicsAlterations to hormone regulated defense and stress response networks contribute to the greater growth of Arabidopsis F1 hybrids
Heterosis, or hybrid vigor, has been exploited in agriculture to deliver increases in crop yields for over a century, yet the molecular basis is not well understood We have studied the transcriptomes of 15 day old seedlings from intraspecific Arabidopsis hybrids with varying levels of heterosis and...
ORGANISM(S): Arabidopsis thaliana 
2015-10-01 | E-GEOD-64475 | biostudies-arrayexpress
UnknownCardiac disease is linked to adiposity in male gorillas (Gorilla gorilla gorilla).
Not available
S-EPMC6594625 | biostudies-literature
UnknownCannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference.
Not available
S-EPMC5727179 | biostudies-literature
GenomicsNCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal melanocytes and melamoma cell lines reveal defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma. Cultures of normal human melanocytes (NHMs) and melanoma lines were analyzed to determine whether global patterns of gene expression could predict the efficacy of DNA damage cell cycle checkpoints...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7469 | biostudies-arrayexpress
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