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Dengue viruses (DENV) are generally maintained in a cycle which requires horizontal transmission via their arthropod vector, Ae. Aegypti, to the vertebrate host. One important consequence of this process is the interference of these arboviruses with both invertebrate and vertebrate immune systems. W...
ORGANISM(S): Aedes aegypti 
We studied potential interactions between dengue viral particles and Aedes aegypti mosquito salivary proteins by mass spectometry
ORGANISM(S): Aedes aegypti Dengue virus 
2021-05-12 | PXD024959 | Pride
Amplicon-based DENV genome
MicroRNAs (miRNA) have alternative forms known as isomiRs, which differ from each other by a few nucleotides. Next generation sequencing platforms facilitate identification of these isomiRs and recent discoveries regarding their functional importance have increased our understandings of the regulato...
ORGANISM(S): Aedes aegypti 
Transcriptional analysis of DENV-elicited inflammation following experimental human DENV-1 challenge
Host factors are essential for efficient amplification of Dengue virus (DENV), yet the current knowledge of these cellular proteins remains limited. Here, we used quantitative thiouridine cross-linking mass spectrometry (qTUX-MS) to cross-link proteins to viral RNA during a live DENV infection in ce...
ORGANISM(S): Homo sapiens (Human) 
2016-09-26 | PXD003593 | Pride
Transcriptional analysis of DENV-elicited inflammation following experimental human DENV-3 challenge
The ability of many viruses to manipulate the host antiviral immune response often results in complex host-pathogen interactions. In order to study the interaction of dengue virus (DENV) with the Aedes aegypti immune response, we have characterized the DENV infection-responsive transcriptome of the ...
ORGANISM(S): Aedes aegypti 
scRNAseq analysis of DENV-2 infected B cells
We measured fever-day-specific genome-wide transcript abundance patterns in 105 peripheral blood mononuclear cell (PBMC) samples collected from 41 children hospitalized with dengue virus (DENV) infection in Nicaragua, and from 8 healthy controls. DF1 = primary DF; DF2 = secondary DF; DHF = Dengue H...
ORGANISM(S): Homo sapiens 
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