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MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
ProteomicsDeoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development
Pancreatic diseases including diabetes and exocrine insufficiency would benefit from therapies that reverse cellular loss and/or restore cellular mass. The identification of molecular pathways that influence cellular growth is therefore critical for future therapeutic generation. Deoxyhypusine synth...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-10-30 | MSV000099697 | MassIVE
ProteomicsDeoxyhypusine synthase (DHPS) mutations alter the post-translational modification of eukaryotic initiation factor 5A (eIF5A) resulting in impaired human and mouse neural homeostasis
DHPS deficiency is a rare genetic disease caused by biallelic hypomorphic variants in the Deoxyhypusine synthase (DHPS) gene. The DHPS enzyme functions in mRNA translation by catalyzing the post-translational modification, and therefore activation, of the eukaryotic initiation factor 5A (eIF5A). The...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-06-06 | MSV000092112 | MassIVE
GenomicsDeoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype
Deoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype
PRJNA604198 | ENA
TranscriptomicsDeoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype
Obesity is characterized by adipose tissue expansion, macrophage infiltration, and the development of chronic low-grade meta-inflammation that drives insulin resistance and metabolic dysfunction. Eukaryotic translation initiation factor 5A (eIF5A) is the only protein known to be uniquely post-transl...
ORGANISM(S): Mus musculus 
2021-09-15 | GSE144614 | GEO
UnknownEssential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
Not available
S-EPMC3220921 | biostudies-literature
ProteomicsA Polyamine-mediated Posttranslational Modification Required For Macrophage Tissue Residency – Differential proteome analysis of DHPS deficient macrophages
Tissue resident macrophages (MTRs) regulate tissue repair and homeostasis by clearing cell debris, and are thought to form the first line of defense against pathogens. MTRs form early in life and self-renew locally. However, during tissue damage or disease, bone-marrow derived monocytes enter tissue...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD054670 | Pride
Eif5a Dia Spectronaut Dda spectral library Tissue resident macrophage proteomics Maxquant Label-free quantification Deoxyhypusine synthase (dhps) Hypusine 
UnknownRecessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.
Not available
S-EPMC6369575 | biostudies-literature
UnknownDeoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype.
Not available
S-EPMC8432737 | biostudies-literature
UnknownNew Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
Not available
S-EPMC8323115 | biostudies-literature
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