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ProteomicsStaphylococcus aureus HG001 - A peptide resource for the analysis of Staphylococcus aureus in host-pathogen interaction studies
Staphylococcus aureus HG001, detection of staphyococcal proteins; bacteria cultivated in TSB; samples mix of exponential, stationary (t0) and post-stationary (t4) growth
ORGANISM(S): Staphylococcus aureus 
2015-07-31 | PXD000702 | Pride
Q exactive Staphylococcus aureus hg001 
ProteomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells
We comparatively analyzed survival and physiological adaptation of S. aureus HG001 to two human lung epithelial cell lines (S9 and A549), and human embryonic kidney cells (HEK 293). Combining enrichment of bacteria from host-pathogen assays by cell sorting and quantitation of the pathogen´s proteome...
ORGANISM(S): Staphylococcus aureus 
2014-09-01 | PXD001003 | Pride
Cell culture infection model Bacterial adaptation to internalization in host cells Q exactive Staphylococcus aureus hg001 
TranscriptomicsComparison of bone marrow-derived macrophages from BALB/c and C57BL/6 mice with and without interferon-gamma stimulation.
ABSTRACT Macrophages are essential components of the innate immune system and crucial for pathogen elimination in early stages of infection. We previously observed that bone marrow-derived macrophages (BMM) from C57BL/6 mice exhibited increased killing activity against Burkholderia pseudomallei comp...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-39349 | biostudies-arrayexpress
TranscriptomicsActivity of SigB Modulates Virulence Gene Expression in a Murine Staphylococcus aureus Infection Model but Does Not Influence the Host Kidney Gene Expression
Background. Infections caused by Staphylococcus aureus are associated with significant morbidity and mortality and are an increasing threat not only in hospital settings. The expression of the staphylococcal virulence factor repertoire is known to be affected by the alternative sigma factor B (SigB...
ORGANISM(S): Mus musculus 
2011-10-23 | E-GEOD-28540 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver after 4.5 days of repeated combined acoustic and restraint stress vs. control
Stress is a powerful modulator of neuroendocrine, behavioral and immunological functions. After 4.5 days of repeated combined acoustic and restraint stress as a murine model of chronic psychological stress severe metabolic dysregulations became detectable in female BALB/c mice. Stress-induced altera...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-11125 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver after combined acoustic and restraint stress compared to non-stressed control mice
Stress is a powerful modulator of neuroendocrine, behavioral and immunological functions. After 4.5 days of repeated combined acoustic and restraint stress as a murine model of chronic psychological stress severe metabolic dysregulations became detectable in female BALB/c mice. Stress-induced altera...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-11126 | biostudies-arrayexpress
TranscriptomicsTargeted transcriptome analysis of the SigB regulon in Bacillus subtilis
Bacillus subtilis is exposed to a wide range of transitory stress and starvation conditions. Here we investigate the expression changes observed in the B. subtilis wild type strain 168 and its isogenic sigB mutant(BSM29) with respect to each stress condition tested. Gene expression was queried for t...
ORGANISM(S): Bacillus subtilis 
2012-03-14 | E-GEOD-32895 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver gene expression after a single acute 2h exposure to combined acoustic and restraint stress vs. control
Stress is a powerful modulator of neuroendocrine, behavioral and immunological functions. After 4.5 days of repeated combined acoustic and restraint stress as a murine model of chronic psychological stress severe metabolic dysregulations became detectable in female BALB/c mice. Stress-induced altera...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-11123 | biostudies-arrayexpress
TranscriptomicsIncreased expression of Bcl11b in human transformed T cell lines leads to chemoresistance accompanied by G1 accumulation.
ABSTRACT Background: The expression of BCL11B has been reported in normal and transformed cells derived from T-lymphocytes, neurons, keratinocytes and recently in a subset of squamous cell carcinomas. Despite the rapidly accumulating knowledge concerning Bcl11b biology, the contribution of this prot...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-21382 | biostudies-arrayexpress
MetabolomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells (NMR assay)
Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival an...
2015-07-01 | MTBLS102 | MetaboLights
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