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TranscriptomicsModulation of gene expression in U251 glioblastoma cells by binding of mutant p53 to intronic and intergenic sequences
Missense point mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines derived thereof. Mutant p53 (mutp53) proteins have lost sequence-specific DNA binding, but have retained the ability to interact in a structure-selective manner with non-B DNA and to act a...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13991 | biostudies-arrayexpress
TranscriptomicsChIP analysis on a custom tiling array of U251 human glioblastoma cell line
Missense mutations in the TP53 gene are frequent genetic alterations in human tumor tissue and cell lines. In contrast to wild-type p53, the mutant p53 (mutp53) protein has lost the transcriptional activity towards pro-apoptotic and growth arrest genes, but retained the property to interact with DNA...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-35453 | biostudies-arrayexpress
TranscriptomicsGene expression and ChIP-chip analysis of U251 human glioblastoma cell line
Using human U251 glioblastoma cells with endogenous mutp53 expression as a model, we performed a ChIP-chip analysis of mutp53 binding sites on a custom tiling array, coupled with global expression profiling and an analysis of the epigenetic status of mutp53 regulated promoters. Mutp53 binds preferen...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-35500 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of U251 human glioblastoma cell line
The human TP53 gene is frequently mutated in tumors and cell lines. Unlike other tumor suppressors that are commonly inactivated by deletions or nonsense mutations, the majority of p53-mutations are missense point mutations that result in the expression of a full-length protein with an altered amino...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-35454 | biostudies-arrayexpress
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice [aCGH]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-31097 | biostudies-arrayexpress
TranscriptomicsMammary carcinomas in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-29117 | biostudies-arrayexpress
TranscriptomicsInvoluted normal mammary gland in WAP-SV40 transgenic mice [gene expression]
Transgenic expression in mice of two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens, in the mammary epithelium recapitulates loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. In primiparous ...
ORGANISM(S): Mus musculus 
2012-10-31 | E-GEOD-33038 | biostudies-arrayexpress
TranscriptomicsExpression of mutant p53 in Mammary carcinomas in WAP-SV40 transgenic mice
Upon induction, WAP-T mice express two synergistically acting SV40 early region encoded proteins, large (LT) and small (sT) tumor antigens in the mammary epithelium, recapitulating thereby the loss of p53 and Rb function and deregulation of PP2A-controlled mitogenic pathways in human breast cancer. ...
ORGANISM(S): Mus musculus 
2013-12-18 | E-GEOD-53395 | biostudies-arrayexpress
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